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Debt - December 2016 Convertible debt (Details)
1 Months Ended 12 Months Ended
Mar. 16, 2018
USD ($)
shares
Jan. 31, 2019
USD ($)
shares
Aug. 31, 2018
USD ($)
shares
Jul. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
$ / shares
Lender
Dec. 31, 2018
USD ($)
item
Dec. 31, 2019
USD ($)
Oct. 31, 2019
USD ($)
May 31, 2019
USD ($)
Jun. 30, 2017
USD ($)
Debt                    
Aggregate principal amount               $ 550,000    
Convertible promissory notes, December 2016                    
Debt                    
Aggregate principal amount         $ 2,500,000          
Number of lenders | Lender         3          
Proceeds from issuance of convertible debt         $ 2,000,000          
Unamortized note discount         $ 500,000          
Conversion price (in dollars per share) | $ / shares         $ 64.75          
Revised principal value of debt                   $ 2,625,338
Fair value of notes         $ 11,161,000          
Difference between the fair value of the notes and the principal balance         $ 1,035,661          
Amortization period of such difference amount         29 months          
Interest Payable $ 534,775   $ 479,808              
Debt legal fee $ 169,950                  
Repayment of accrued interest   $ 446,729                
Shares issued (in shares) | shares 4,081 19,751 4,582              
Convertible promissory notes, December 2016 | Convertible Long-term Debt                    
Debt                    
Number of debt instrument extinguished | item           2        
Unamortized balance of notes payable           $ 10,553,888 $ 0      
Convertible note purchase agreement                    
Debt                    
Aggregate principal amount         $ 12,500,000          
Interest rate (as a percent)       10.00%            
Debt instrument, frequency of periodic payment       P6M            
Accrued interest capitalized to principal of debt                   $ 125,338
Convertible promissory notes, July 2017                    
Debt                    
Aggregate principal amount       $ 7,500,000            
Number of lenders       4            
Proceeds from issuance of convertible debt       $ 6,000,000            
Unamortized note discount       $ 1,500,000            
2019 Exchange Note 1                    
Debt                    
Aggregate principal amount                 $ 10,125,339  
Interest rate (as a percent)                 10.00%  
2019 Exchange Note 2                    
Debt                    
Aggregate principal amount                 $ 2,296,926  
Interest rate (as a percent)                 10.00%  
Napo | Napo December 2016 and Napo July 2017 Notes                    
Debt                    
Aggregate principal amount                 $ 10,125,339  
Unamortized premium                 249,987  
Carrying amount of Notes issued                 10,375,326  
Napo | 2019 Exchange Note 1                    
Debt                    
Aggregate principal amount                 10,125,339  
Accrued interest capitalized to principal of debt                 410,562  
Napo | 2019 Exchange Note 1                    
Debt                    
Aggregate principal amount                 $ 10,535,900