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Stockholders' Equity (Details)
Jun. 03, 2019
May 29, 2019
Sep. 30, 2019
shares
Dec. 31, 2018
shares
Stockholders’ Equity        
Reverse stock split ratio 0.015 0.0667    
Shares of common stock reserved for issuance        
Options issued and outstanding     3,821,690 42,979
Options available for grant under stock option plans     554,016 2,327
RSUs awards issued and outstanding     5,613 5,613
Warrants issued and outstanding     19,421,892 34,682
Convertible warrants     9,580  
Total     25,262,276 146,792
Convertible notes        
Shares of common stock reserved for issuance        
Convertible warrants       10,849
Inducement options issued and outstanding        
Shares of common stock reserved for issuance        
Options issued and outstanding       2,985
Series A convertible preferred stock        
Shares of common stock reserved for issuance        
Convertible warrants     473,565 47,357
Series B convertible preferred stock        
Shares of common stock reserved for issuance        
Convertible warrants     985,500  
Common Stock | Common stock - voting        
Stockholders’ Equity        
Common stock, shares authorized     150,000,000 150,000,000
Common Stock | Common stock - non-voting        
Stockholders’ Equity        
Common stock, shares authorized     50,000,000 50,000,000