CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)	3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Dec. 31, 2018
Cash flows from operating activities
Net loss	$ (16,721,117)	$ (7,657,183)	$ (25,024,988)	$ (13,353,820)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization expense			873,142	659,230
Impairment of indefinite-lived intangible assets	4,000,000	0	4,000,000	0
Interest paid on the conversion of debt to equity				59,737
Common stock issued in exchange for services rendered				6,425
Loss on extinguishment of debt	2,663,198		4,605,158
Amortization of operating lease right-of-use-assets			362,884
Stock-based compensation			872,876	736,697
Amortization of debt issuance costs and debt discount			3,879,353	817,927
Change in fair value of warrants, conversion option and derivative liability			(161,031)	(141,230)
Change in fair value of of derivative liability				(3,000)
Changes in assets and liabilities.
Accounts receivable			(1,101,530)	(115,954)
Other receivable			(86,626)	(69,075)
Inventory			948,945	(771,688)
Prepaid expenses and other current assets			247,628	(785,711)
Deferred collaboration revenue				(177,389)
Operating lease liabilities			(230,351)
Accounts payable			976,027	(2,354,183)
Accrued expenses			1,067,296	473,521
Total cash used in operating activities			(8,771,217)	(15,018,513)
Cash flows from investing activities
Purchase of equipment			(6,508)	(6,527)
Total cash used in investing activities			(6,508)	(6,527)
Cash flows from financing activities
Proceeds from issuance of short-term notes payable			5,050,000
Proceeds from issuance of long term debt				2,310,000
Repayment of notes payable			(100,000)	(1,689,200)
Proceeds from issuance of common stock through a stock purchase agreement with a private investor				1,305,774
Proceeds from the issuance of common stock in a private investment in public entities with existing investors				750,100
Proceeds from the issuance of common stock, March 2019			266,266
Fractional common shares repurchased				(30)
Payment of offering costs for July 2019 registered offering			(3,000)
Total cash provided by financing activities			7,816,161	16,676,646
Net increase (decrease) in cash			(961,564)	1,651,606
Cash at beginning of period			2,568,191	759,867	$ 759,867
Cash at end of period	$ 1,606,627	2,411,473	1,606,627	2,411,473	$ 2,568,191
Supplemental schedule of non-cash financing and investing activities
Interest paid on long-term debt				19,344
Deemed dividend attributable to preferred stock		$ (995,000)		(995,000)
Common stock exchanged for CVP Exchange Note 1 and related interest			5,584,153
Repayment of accrued interest on Kingdon note payable by issuance of common stock			446,729
Repayment of CVP Note Payable principal and interest by issuance of common stock			8,224,924
Issuance of March 2019 letter of credit warrant			$ 116,297
Issuance of warrants with short-term Notes Payable			5,005,739
Accrual of offering costs for July 2019 registered offering			$ 332,768
Private Investment in Public Entities March 2018
Cash flows from financing activities
Proceeds from the issuance of common stock				5,000,000
Proceeds from the issuance of convertible preferred stock, March 2018				9,000,002
Proceeds from issuance of common stock, January to April 2019
Cash flows from financing activities
Proceeds from the issuance of common stock			$ 2,602,895
Jaguar Notes Payable
Supplemental schedule of non-cash financing and investing activities
Common stock issued as redemption of notes payable and related interest				1,153,408
Napo convertible debt
Supplemental schedule of non-cash financing and investing activities
Common stock issued as redemption of notes payable and related interest				$ 1,158,738