CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Cash flows from operating activities
Net loss	$ (8,303,871)	$ (5,696,637)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization expense	436,880	329,561
Interest paid on the conversion of debt to equity		20,496
Common stock issued in exchange for services rendered		6,425
Loss on extinguishment of debt	1,941,960
Amortization of operating lease right-of-use-assets	56,575
Stock-based compensation	426,508	272,243
Amortization of debt issuance costs and debt discount	178,180	403,824
Change in fair value of warrants, conversion option and derivative liability	46,057	267,854
Changes in assets and liabilities
Accounts receivable	80,925	104,849
Other receivable	3,822	(1,034)
Inventory	382,130	(255,703)
Prepaid expenses and other current assets	149,929	130,694
Other non-current assets	27,172
Deferred collaboration revenue		(177,389)
Operating lease liabilities	(93,235)
Accounts payable	1,149,632	(4,192,753)
Accrued expenses	51,762	(834,123)
Total cash used in operating activities	(3,465,574)	(9,621,693)
Cash flows from investing activities
Purchase of equipment		(6,527)
Total cash used in investing activities		(6,527)
Cash flows from financing activities
Proceeds from issuance of notes payable	800,000
Proceeds from issuance of long term debt		2,310,000
Repayment of notes payable	(100,000)	(1,689,199)
Proceeds from issuance of common stock through a stock purchase agreement with a private investor November 2017		1,305,774
Issuance of common stock, January 2019, net	266,266
Total cash provided by financing activities	3,469,161	16,676,677
Net increase in cash	3,587	7,048,457
Cash at beginning of period	2,568,191	759,867
Cash at end of period	2,571,778	7,808,324
Supplemental schedule of non-cash financing and investing activities
Interest paid on long-term debt		19,344
Deemed dividend attributable to preferred stock		995,000
Repayment of accrued interest on note payable by issuance of common stock	446,729
Repayment of Note Payable principle by issuance of common stock	4,374,108
Issuance of March 2019 letter of credit warrant	$ 116,297
Issuance of warrants with Notes Payable	892,713
Private Investment in Public Entities December 2017
Cash flows from financing activities
Proceeds from the issuance of common stock		750,100
Private Investment in Public Entities March 2018
Cash flows from financing activities
Proceeds from the issuance of common stock		5,000,000
Proceeds from the issuance of convertible preferred stock, March 2018		9,199,002
Issuance costs associated with the issuance of convertible preferred stock, March 2018		(199,000)
Private Investment in Public Entities January to March 2019
Cash flows from financing activities
Proceeds from the issuance of common stock	$ 2,502,895
Jaguar Notes Payable
Supplemental schedule of non-cash financing and investing activities
Common stock issued as redemption of notes payable and related interest		950,000
Napo convertible debt
Supplemental schedule of non-cash financing and investing activities
Common stock issued as redemption of notes payable and related interest		$ 1,158,308