CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Revenue
Total revenue	$ 4,416,145	$ 4,361,186
Operating expenses
Cost of product revenue	2,765,746	880,405
Research and development	5,154,748	4,269,455
Sales and marketing	9,831,576	3,083,739
General and administrative	12,277,222	11,247,647
Impairment of goodwill	5,210,821	16,827,000
Impairment of indefinite-lived assets	0	2,300,000
Total operating expenses	35,240,113	38,608,246
Loss from operations	(30,823,968)	(34,247,060)
Interest expense	(2,628,685)	(1,209,632)
Other income, net	315,691	88,549
Change in fair value of warrants, derivative liability and conversion option liability	331,016	695,341
Gain on Valeant settlement	1,204,333
Loss on extinguishment of debt	(544,444)	(477,054)
Net loss before income tax	(32,146,057)	(35,149,856)
Income tax benefit		13,181,242
Net loss	$ (32,146,057)	$ (21,968,614)
Net loss per share - basic and diluted (in dollars per share)	$ (2.19)	$ (7.59)
Weighted-average shares outstanding, basic and diluted (in shares)	14,681,044	2,895,729
Product revenue
Revenue
Total revenue	$ 4,238,756	$ 1,485,114
Collaboration revenue
Revenue
Total revenue	$ 177,389	$ 2,876,072