Stock Based Compensation (Tables)

12 Months Ended

Dec. 31, 2018

Stock Based Compensation

Summary of incentive plan activity

				Weighted		Weighted Average
	Shares	Stock		Average		Remaining	Aggregate
	Available	Options	RSUs	Stock Option		ContractualLife	Intrinsic
	for Grant	Outstanding	Outstanding	Exercise Price		(Years)	Value*
Outstanding at December 31, 2017	3,619	229,575	392,904	$	28.05	8.31	$	—
Additional shares authorized	2,877,766	—	—		—	—
Options granted	(2,868,673)	2,868,673	—		1.60	—		—
Options cancelled	150,180	(154,100)	—		4.57	—		—
Outstanding at December 31, 2018	162,892	2,944,148	392,904	$	5.81	9.24	$	—
Exercisable at December 31, 2018		616,309		$	10.86	8.90	$	—
Vested and expected to vest at December 31, 2018		2,849,994		$	6.02	9.24	$	—

*    Fair market value of JAGX stock on December 31, 2018 was $0.23 per share.

Summary of stock-based compensation expense

	Year Ended
	December 31,
	2018		2017
Research and development expense	$	579,641	$	216,932
Sales and marketing expense		96,730		32,325
General and administrative expense		1,347,503		565,356
Total	$	2,023,874	$	814,613

Employee stock options

Stock Based Compensation

Schedule of estimated grant-date fair value of stock options calculated using the Black-Scholes option-pricing model

	Year Ended
	December 31,
	2018		2017
Weighted-average volatility	87.4 - 105.9	%	74.3 - 90.5	%
Weighted-average expected term (years)	5.1 - 5.8		5.1 - 5.8
Risk-free interest rate	2.6 - 2.9	%	2.0 - 2.3	%
Expected dividend yield	—		—

Non-employee stock options

Stock Based Compensation

Schedule of estimated grant-date fair value of stock options calculated using the Black-Scholes option-pricing model

	Year Ended
	December 31,
	2018		2017
Weighted-average volatility	83.6 - 89.2	%	85.4 - 85.7	%
Weighted-average expected term (years)	9.1 - 9.7		9.8 - 10.0
Risk-free interest rate	2.6 - 3.0	%	2.4 - 2.5	%
Expected dividend yield	—		—