Debt and Warrants (Tables)

12 Months Ended

Dec. 31, 2018

Debt and Warrants

Schedule of aggregate convertible debt

	December 31,		December 31,
	2018		2017
February 2015 convertible debt		—		150,000
June 2017 convertible debt		740,882		1,613,089
Napo convertible debt		10,553,888		12,153,389
	$	11,294,770	$	13,916,478
Less: unamortized debt discount and debt issuance costs		(55,600)		(261,826)
Net convertible debt obligation	$	11,239,170	$	13,654,652
Convertible debt - non-current, net of discount		—		10,982,437
Convertible debt - current, net of discount	$	11,239,170	$	2,672,215

Schedule of notes payable

	December 31,		December 31,
	2018		2017
December 2017 note payable	$	1,673,237	$	1,587,500
February 2018 note payable		2,359,750		—
March 2018 note payable		1,147,870		—
	$	5,180,857	$	1,587,500
Less: unamortized net discount and debt issuance costs		(335,282)		(446,347)
Net convertible notes payable obligation	$	4,845,575	$	1,141,153

Schedule of long-term debt obligation

	December 31,		December 31,
	2018		2017
Debt and unpaid accrued end-of-term payment	$	—	$	1,636,639
Unamortized note discount		—		(6,615)
Unamortized debt issuance costs		—		(20,780)
Net debt obligation	$	—	$	1,609,244
Current portion of long-term debt	$	—	$	1,609,244
Long-term debt, net of discount		—		—
Total	$	—	$	1,609,244

Summary of warrant activity

	Year ended December 31,
	2018	2017
Warrants outstanding, beginning balance	321,314	397,904
Issuances	2,166,588	106,376
Exercises	—	(60,553)
Expirations and cancellations	(60,249)	(122,413)
Warrants outstanding, end of period	2,427,653	321,314