X0306 4 2021-05-18 0 0001585608 Jaguar Health, Inc. JAGX 0001255743 BOCHNOWSKI JAMES J C/O JAGUAR HEALTH, INC. 200 PINE STREET, SUITE 400 SAN FRANCISCO CA 94104 1 0 0 0 Stock option (right to buy) 1.24 2021-05-18 4 A 0 78750 0 A 2031-05-18 Common Stock 78750 78750 D Restricted stock units 2021-05-18 4 A 0 39400 0 A Common Stock 39400 39400 D Granted pursuant to the issuer's 2014 Stock Incentive Plan. The option and restricted stock unit grants were approved by the issuer's board of directors on May 18, 2021. The options will vest in full on May 18, 2022, the first anniversary of the grant date, so long as the director continues to serve on the board of directors of the issuer. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units vest in full on May 18, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice. /s/ James J. Bochnowski 2021-05-19