X0306 4 2021-04-05 0 0001585608 Jaguar Health, Inc. JAGX 0001622052 King Steven R. C/O JAGUAR HEALTH, INC. 200 PINE STREET, SUITE 400 SAN FRANCISCO CA 94104 0 1 0 0 Chief of Sustainable Supply Stock option (right to buy) 1.99 2021-04-05 4 A 0 240000 0 A 2031-04-05 Common Stock 240000 240000 D Restricted stock units 2021-04-05 4 A 0 120000 0 A Common Stock 120000 120000 D Granted pursuant to the issuer's 2014 Stock Incentive Plan. The option and restricted stock unit grants were approved by the issuer's board of directors on April 5, 2021. The option will vest ratably on a monthly basis over 36 months from the grant date, so long as the executive remains employed by the issuer. Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. The restricted stock units vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date or dates provided in the grant notice. /s/ Lisa A. Conte, Attorney-in-Fact 2021-04-07