X0306 4 2018-07-18 0 0001585608 Jaguar Health, Inc. JAGX 0001588209 Siegel Jonathan B. C/O JAGUAR HEALTH, INC. 201 MISSION STREET, SUITE 2375 SAN FRANCISCO CA 94105 1 0 0 0 Common Stock 2018-07-18 4 P 0 5000 1.0952 A 14732 I See footnote Securities held directly by JBS Healthcare Ventures LLC. Mr. Siegel, by virtue of his position as the sole member of JBS Healthcare Ventures LLC, may be deemed to beneficially own the securities held by JBS Healthcare Ventures LLC for purposes of Section 16. /s/ Karen S. Wright, Attorney-in-Fact 2018-07-20