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Net Loss Per Share Attributable to Common Stockholders- Calculation (Details) - USD ($)
3 Months Ended 12 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Dec. 31, 2016
Dec. 31, 2015
Calculation of basic and diluted net loss per common share        
Net loss attributable to common stockholders $ (4,715,358) $ (3,984,204) $ (14,733,780) $ (16,637,924)
Shares used to compute net loss per common share, basic and diluted (in shares) 14,157,351 9,307,354 10,951,178 6,153,139
Net loss per share attributable to common shareholders, basic and diluted $ (0.33) $ (0.43) $ (1.35) $ (2.70)