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Commitments and Contingencies - Contract Manufacturing Commitment (Details)
1 Months Ended 12 Months Ended
Jul. 15, 2016
EUR (€)
Mar. 29, 2016
EUR (€)
Dec. 31, 2015
EUR (€)
shares
Jun. 26, 2014
EUR (€)
item
shares
May 31, 2015
EUR (€)
Dec. 31, 2016
EUR (€)
shares
item
Dec. 31, 2016
USD ($)
item
Dec. 31, 2015
USD ($)
Nov. 08, 2016
$ / shares
Mar. 31, 2016
EUR (€)
Jun. 30, 2015
EUR (€)
Mar. 31, 2015
$ / shares
Mar. 31, 2015
EUR (€)
Mar. 25, 2015
EUR (€)
Oct. 30, 2014
Commitments and Contingencies                              
Number of warrants issued to purchase shares of common stock (in shares) | shares     26,785     67,655                  
Exercise price as a percentage of initial public offering price                             80.00%
Exercise price (in dollars per share) | $ / shares                 $ 0.01            
Accrued liabilities                              
Commitments and Contingencies                              
Contract amortization costs included in accrued liabilities | $             $ 0 $ 110,141              
Transfer Agreement | Manufacturer                              
Commitments and Contingencies                              
Prepayment of start-up fee       € 500,000 € 500,000 € 500,000                  
Prepayment of start-up fee which is to be paid at the earlier to occur of September 15, 2014 or the closing date of an initial public offering       250,000                      
Prepayment of start-up fee which is to be paid at the time of installation and qualification of the Company's equipment       250,000                      
Prepayment related to technology transfer       620,000 215,000                    
Prepayment related to technology transfer which is to be paid within five days of the signature of the Transfer Agreement       310,000                      
Prepayment related to technology transfer which is to be paid after the delivery of a final study report       310,000                      
Prepayment for design of a portion of the Manufacturer's facility which is to be paid within five days of the signature of the Transfer Agreement       € 100,000                      
Period within which prepayment for design of a portion of the Manufacturer's facility is payable from signature of the Transfer Agreement       5 days                      
Bonus fee payable     € 150,000.00 € 300,000                      
Number of installments | item       2                      
Bonus fee paid € 150,000   150,000   € 150,000 € 150,000                  
Aggregate amount payable to Manufacturer upon the delivery of agreed-upon levels of satisfactory product pursuant to the agreement     € 250,000 € 500,000           € 250,000     € 250,000    
Number of warrants issued to purchase shares of common stock (in shares) | shares       16,666                      
Exercise price as a percentage of initial public offering price       90.00%                      
Exercise price (in dollars per share) | $ / shares                       $ 6.30      
Remaining balance due related to prepayment of technology transfer                           € 310,000  
Increase in prepayment for design of portion of manufacturer facility payable within specified days of signature of agreement                           170,000  
Transfer Agreement | API                              
Commitments and Contingencies                              
Amount of product supplied at no cost (in Kg) | item           400 400                
Payments made   € 250,000                          
Amendment to Transfer Agreement first portion due | Manufacturer                              
Commitments and Contingencies                              
Prepayment related to technology transfer                           € 215,000  
Payments related to design of a portion of manufacturing facility           € 150,000                  
Amendment to Transfer Agreement second portion due | Manufacturer                              
Commitments and Contingencies                              
Prepayment related to technology transfer                     € 95,000        
Payments related to design of a portion of manufacturing facility           € 20,000