Statement of Changes in Common Stock, Convertible Preferred Stock and Stockholders' Equity (Deficit) - USD ($)	Common Stock	Additional paid-in capital	Accumulated deficit	Total
Balance at Dec. 31, 2013	$ 267	$ 366,083	$ (801,203)	$ (434,853)
Balance (in shares) at Dec. 31, 2013	2,666,666
Increase (decrease) in Stockholders' Equity (Deficit)
Conversion of convertible notes payable	$ 21	524,979		525,000
Conversion of convertible notes payable (in shares)	207,664
Stock-based compensation		164,156		164,156
Beneficial conversion feature on notes payable		614,557		614,557
Warrants issued in connection with the line of credit		114,300		114,300
Warrants issued in connection with the transfer agreement		37,840		37,840
Deemed dividends on Series A		(610,889)		(610,889)
Accretion of issuance costs		(35,784)		(35,784)
Net and comprehensive loss			(8,609,575)	(8,609,575)
Balance at Dec. 31, 2014	$ 288	1,175,242	(9,410,778)	(8,235,248)
Balance (in shares) at Dec. 31, 2014	2,874,330
Increase (decrease) in Stockholders' Equity (Deficit)
Issuance of common stock in initial public offering, net of discounts and commissions of $1,209,802, offering costs of $2,897,825 and offering costs in the form of common stock warrants of $400,400	$ 286	15,511,974		15,512,260
Issuance of common stock in initial public offering, net of discounts and commissions (in shares)	2,860,000
Warrant, issued in conjunction with the initial public offering		400,400		400,400
Conversion of preferred stock into common stock upon initial public offering	$ 201	7,651,087		7,651,288
Conversion of preferred stock into common stock upon initial public offering (in shares)	2,010,596
Conversion of preferred stock warrant liability into additional paid-in capital		1,150,985		1,150,985
Conversion of convertible notes payable	$ 37	2,099,963		2,100,000
Conversion of convertible notes payable (in shares)	374,997
Stock-based compensation		992,165		992,165
Beneficial conversion feature on notes payable		1,202,521		1,202,521
Deemed dividends on Series A		(263,060)		(263,060)
Accretion of issuance costs		(83,314)		(83,314)
Napo license fee abatement		250,000		250,000
Issuance of common stock upon exercise of stock options		12,650		12,650
Issuance of common stock upon exercise of stock options (in shares)	5,000
Net and comprehensive loss			(16,291,550)	(16,291,550)
Balance at Dec. 31, 2015	$ 812	$ 30,100,613	$ (25,702,328)	$ 4,399,097
Balance (in shares) at Dec. 31, 2015	8,124,923