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                          June 4, 2021

       Lisa A. Conte
       Chief Executive Officer
       Jaguar Health, Inc.
       200 Pine Street, Suite 400
       San Francisco, CA 94104

                                                        Re: Jaguar Health, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed May 28, 2021
                                                            File No. 333-256634

       Dear Ms. Conte:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact
Christine Westbrook at 202-551-5019 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Michael S. Lee, Esq.