Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Operating activities
Net loss	$ (113,012)	$ (192,036)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	5,368	9,207
Depreciation and amortization	8,830	1,578
Non-cash lease expense	2,771	1,043
Impairment of long-lived assets	3,593	0
Changes in operating assets and liabilities:
Accounts receivable	(125)	288
Prepaid expenses and other current assets	604	(281)
Prepaid research and development	0	12,014
Other long-term assets and liabilities	741	(5,615)
Accounts payable	(1,194)	216
Accrued expenses and other liabilities	(7,712)	2,202
Net cash used in operating activities	(100,136)	(171,384)
Investing activities
Purchase of property and equipment	(1,615)	(2,866)
Net cash used in investing activities	(1,615)	(2,866)
Financing activities
Proceeds from stock option exercises	98	1,444
Proceeds from stock issuances pursuant to employee stock purchase plan	308	439
Proceeds from initial public offering, net of issuance costs	0	232,546
Net cash provided by financing activities	406	234,429
Net (decrease) increase in cash, cash equivalents and restricted cash	(101,345)	60,179
Cash, cash equivalents and restricted cash at beginning of year	233,312	173,133
Cash, cash equivalent and restricted cash at end of year	131,967	233,312
Supplemental disclosure of noncash activities
Right-of-use assets obtained in exchange for operating lease liabilities	$ 19,245	$ 13,499