Commitments and Contingencies - Additional Information (Details)	1 Months Ended						3 Months Ended	12 Months Ended
	Sep. 30, 2021	Jul. 31, 2021 USD ($)	Apr. 30, 2021	Jan. 31, 2021 USD ($) Option	Jun. 30, 2020	Dec. 31, 2015	Dec. 31, 2021 USD ($) Option	Dec. 31, 2021 USD ($) Option
Commitments And Contingencies [Line Items]
Existence of option to extend operating lease	true		true		true
Renewal term	2 months		2 months		6 months
Lease extending date	Mar. 31, 2022		Dec. 31, 2021		Oct. 31, 2021
Unconditional purchase obligation							$ 15,800,000	$ 15,800,000
Standby Letters of Credit
Commitments And Contingencies [Line Items]
letter of credit facility		$ 33,000,000.0
Letter of Credit
Commitments And Contingencies [Line Items]
Payment to contract manufacturing organization		$ 29,600,000
Cash collateral for line of credit facility				$ 800,000
Chicago, IL | Letter of Credit
Commitments And Contingencies [Line Items]
letter of credit facility				$ 800,000
Laboratory and Office Space | Chicago, IL
Commitments And Contingencies [Line Items]
Operating lease commencement month and year				2021-05
Initial term of operating lease				11 years
Existence of option to extend operating lease				true
Renewal term				5 years
Annual minimum commitment				$ 1,700,000
Fixed escalations percentage per annum				2.50%
Number of options to extend Lease term | Option				2
Laboratory and Office Space | Redwood City, CA
Commitments And Contingencies [Line Items]
Initial term of operating lease							10 years 6 months	10 years 6 months
Existence of option to extend operating lease								true
Renewal term							5 years	5 years
Annual minimum commitment							$ 2,600,000	$ 2,600,000
Fixed escalations percentage per annum							3.00%	3.00%
Number of options to extend Lease term | Option							2	2
Security deposit							$ 1,000,000.0	$ 1,000,000.0
Payment to landlord for lease payments							$ 4,500,000
Laboratory and Office Space | Menlo Park, California
Commitments And Contingencies [Line Items]
Operating lease commencement date						May 01, 2016
Lease expiration date						Apr. 30, 2021