The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AEROVATE THERAPEUTICS INC | COM | 008064107 | 21,192,215 | 1,561,696 | SH | DFND | 1 | 1,561,696 | 0 | 0 | ||
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 21,755,000 | 1,900,000 | SH | DFND | 1 | 1,900,000 | 0 | 0 | ||
| ALX ONCOLOGY HLDGS INC | COM | 00166B105 | 2,937,979 | 612,079 | SH | DFND | 1 | 612,079 | 0 | 0 | ||
| AMBRX BIOPHARMA INC | SPONSORED ADS | 02290A102 | 114,122,424 | 9,923,689 | SH | DFND | 1 | 9,923,689 | 0 | 0 | ||
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 76,080,000 | 2,000,000 | SH | DFND | 1 | 2,000,000 | 0 | 0 | ||
| ARCELLX INC | COMMON STOCK | 03940C100 | 77,142,000 | 2,150,000 | SH | DFND | 1 | 2,150,000 | 0 | 0 | ||
| AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 913,749 | 392,167 | SH | DFND | 1 | 392,167 | 0 | 0 | ||
| AVIDITY BIOSCIENCES INC | COM | 05370A108 | 11,242,294 | 1,762,115 | SH | DFND | 1 | 1,762,115 | 0 | 0 | ||
| AXONICS INC | COM | 05465P101 | 14,030,000 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | ||
| BIOATLA INC | COM | 09077B104 | 2,007,896 | 1,181,115 | SH | DFND | 1 | 1,181,115 | 0 | 0 | ||
| BIOHAVEN LTD | COM | G1110E107 | 2,131,858 | 81,963 | SH | DFND | 1 | 81,963 | 0 | 0 | ||
| BIOMEA FUSION INC | COM | 09077A106 | 49,135,202 | 3,570,872 | SH | DFND | 1 | 3,570,872 | 0 | 0 | ||
| BRIDGEBIO PHARMA INC | COM | 10806X102 | 122,950,916 | 4,662,530 | SH | DFND | 1 | 4,662,530 | 0 | 0 | ||
| CABALETTA BIO INC | COM | 12674W109 | 43,824,833 | 2,879,424 | SH | DFND | 1 | 2,879,424 | 0 | 0 | ||
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 3,633,552 | 561,600 | SH | DFND | 1 | 561,600 | 0 | 0 | ||
| COGENT BIOSCIENCES INC | COM | 19240Q201 | 9,750,000 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | ||
| CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 32,770,625 | 1,101,904 | SH | DFND | 1 | 1,101,904 | 0 | 0 | ||
| CYMABAY THERAPEUTICS INC | COM | 23257D103 | 57,403,500 | 3,850,000 | SH | DFND | 1 | 3,850,000 | 0 | 0 | ||
| DISC MEDICINE INC | COM | 254604101 | 10,570,500 | 225,000 | SH | DFND | 1 | 225,000 | 0 | 0 | ||
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 16,885,663 | 2,946,887 | SH | DFND | 1 | 2,946,887 | 0 | 0 | ||
| ENLIVEN THERAPEUTICS INC | COM | 29337E102 | 16,620,286 | 1,216,712 | SH | DFND | 1 | 1,216,712 | 0 | 0 | ||
| ERASCA INC | COM | 29479A108 | 21,302,095 | 10,813,246 | SH | DFND | 1 | 10,813,246 | 0 | 0 | ||
| EYEPOINT PHARMACEUTICALS INC | COM NEW | 30233G209 | 25,568,000 | 3,200,000 | SH | DFND | 1 | 3,200,000 | 0 | 0 | ||
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 5,960,082 | 593,043 | SH | DFND | 1 | 593,043 | 0 | 0 | ||
| HARPOON THERAPEUTICS INC | COM NEW | 41358P205 | 217,862 | 54,060 | SH | DFND | 1 | 54,060 | 0 | 0 | ||
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 16,188,000 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | ||
| IMMUNEERING CORP | CLASS A COM | 45254E107 | 32,289,516 | 4,204,364 | SH | DFND | 1 | 4,204,364 | 0 | 0 | ||
| IMMUNOVANT INC | COM | 45258J102 | 47,027,750 | 1,225,000 | SH | DFND | 1 | 1,225,000 | 0 | 0 | ||
| INSMED INC | COM PAR $.01 | 457669307 | 14,518,750 | 575,000 | SH | DFND | 1 | 575,000 | 0 | 0 | ||
| KARUNA THERAPEUTICS INC | COM | 48576A100 | 23,672,600 | 140,000 | SH | DFND | 1 | 140,000 | 0 | 0 | ||
| LONGBOARD PHARMACEUTICALS IN | COM | 54300N103 | 13,083,464 | 2,353,141 | SH | DFND | 1 | 2,353,141 | 0 | 0 | ||
| MARINUS PHARMACEUTICALS INC | COM NEW | 56854Q200 | 21,131,250 | 2,625,000 | SH | DFND | 1 | 2,625,000 | 0 | 0 | ||
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 464,099,700 | 8,142,100 | SH | DFND | 1 | 8,142,100 | 0 | 0 | ||
| NEUMORA THERAPEUTICS INC. | COM | 640979100 | 1,302,256 | 92,293 | SH | DFND | 1 | 92,293 | 0 | 0 | ||
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 55,633,835 | 4,504,764 | SH | DFND | 1 | 4,504,764 | 0 | 0 | ||
| ORCHARD THERAPEUTICS PLC | SPON ADS NEW | 68570P200 | 198,383 | 25,664 | SH | DFND | 1 | 25,664 | 0 | 0 | ||
| PHARVARIS N V | COM | N69605108 | 28,413,670 | 1,361,460 | SH | DFND | 1 | 1,361,460 | 0 | 0 | ||
| PRAXIS PRECISION MEDICINES I | COM | 74006W108 | 16,245,000 | 9,500,000 | SH | DFND | 1 | 9,500,000 | 0 | 0 | ||
| RAPT THERAPEUTICS INC | COM | 75382E109 | 5,401,500 | 325,000 | SH | DFND | 1 | 325,000 | 0 | 0 | ||
| RAYZEBIO INC | COM | 75525N107 | 26,246,239 | 1,182,263 | SH | DFND | 1 | 1,182,263 | 0 | 0 | ||
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 19,486,250 | 850,000 | SH | DFND | 1 | 850,000 | 0 | 0 | ||
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 9,220,500 | 450,000 | SH | DFND | 1 | 450,000 | 0 | 0 | ||
| STOKE THERAPEUTICS INC | COM | 86150R107 | 4,285,960 | 1,087,807 | SH | DFND | 1 | 1,087,807 | 0 | 0 | ||
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 53,262,327 | 1,056,373 | SH | DFND | 1 | 1,056,373 | 0 | 0 | ||
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 | 46,582,669 | 2,621,422 | SH | DFND | 1 | 2,621,422 | 0 | 0 | ||
| VAXCYTE INC | COM | 92243G108 | 33,901,700 | 665,000 | SH | DFND | 1 | 665,000 | 0 | 0 | ||
| VERVE THERAPEUTICS INC | COM | 92539P101 | 4,641,000 | 350,000 | SH | DFND | 1 | 350,000 | 0 | 0 | ||
| VIGIL NEUROSCIENCE INC | COM | 92673K108 | 3,324,477 | 616,786 | SH | DFND | 1 | 616,786 | 0 | 0 | ||
| ZENTALIS PHARMACEUTICALS INC | COM | 98943L107 | 14,042,000 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | ||