The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACCELERON PHARMA INC | COM | 00434H108 | 4,612 | 127,451 | SH | DFND | 1 | 127,451 | 0 | 0 | |
| ACHILLION PHARMACEUTICALS | COM | 00448Q201 | 8,150 | 1,006,128 | SH | DFND | 1 | 1,006,128 | 0 | 0 | |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 23,082 | 901,286 | SH | DFND | 1 | 901,286 | 0 | 0 | |
| ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 178 | 25,307 | SH | DFND | 1 | 25,307 | 0 | 0 | |
| ADVAXIS INC | COM NEW | 007624208 | 9,845 | 920,915 | SH | DFND | 1 | 920,915 | 0 | 0 | |
| AGENUS INC | COM NEW | 00847G705 | 11,331 | 1,578,106 | SH | DFND | 1 | 1,578,106 | 0 | 0 | |
| AGILE THERAPEUTICS INC | COM | 00847L100 | 3,936 | 563,880 | SH | DFND | 1 | 563,880 | 0 | 0 | |
| ALDER BIOPHARMACEUTICALS INC | COM | 014339105 | 55,351 | 1,689,071 | SH | DFND | 1 | 1,689,071 | 0 | 0 | |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 8,548 | 126,120 | SH | DFND | 1 | 126,120 | 0 | 0 | |
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 1,124 | 151,838 | SH | DFND | 1 | 151,838 | 0 | 0 | |
| APPLIED GENETIC TECHNOL CORP | COM | 03820J100 | 169 | 17,321 | SH | DFND | 1 | 17,321 | 0 | 0 | |
| APTOSE BIOSCIENCES INC | COM NEW | 03835T200 | 2,229 | 990,579 | SH | DFND | 1 | 990,579 | 0 | 0 | |
| AQUINOX PHARMACEUTICALS INC | COM | 03842B101 | 2,029 | 151,838 | SH | DFND | 1 | 151,838 | 0 | 0 | |
| ARDELYX INC | COM | 039697107 | 26,811 | 2,071,964 | SH | DFND | 1 | 2,071,964 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 7,763 | 1,150,000 | SH | DFND | 1 | 1,150,000 | 0 | 0 | |
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 1,251 | 62,254 | SH | DFND | 1 | 62,254 | 0 | 0 | |
| ATARA BIOTHERAPEUTICS INC | COM | 046513107 | 3,988 | 186,460 | SH | DFND | 1 | 186,460 | 0 | 0 | |
| AUDENTES THERAPEUTICS INC | COM | 05070R104 | 8,008 | 449,660 | SH | DFND | 1 | 449,660 | 0 | 0 | |
| AVEO PHARMACEUTICALS INC | COM | 053588109 | 968 | 1,087,715 | SH | DFND | 1 | 1,087,715 | 0 | 0 | |
| AVEXIS INC | COM | 05366U100 | 5,434 | 131,858 | SH | DFND | 1 | 131,858 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 8,876 | 298,870 | SH | DFND | 1 | 298,870 | 0 | 0 | |
| CATABASIS PHARMACEUTICALS IN | COM | 14875P107 | 4,928 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| CELLECTAR BIOSCIENCES INC | COM | 15117F302 | 145 | 53,649 | SH | DFND | 1 | 53,649 | 0 | 0 | |
| CELLECTAR BIOSCIENCES INC | *W EXP 08/20/201 | 15117F120 | 13 | 52,999 | SH | DFND | 1 | 52,999 | 0 | 0 | |
| CELLECTIS S A | SPONSORED ADS | 15117K103 | 11,995 | 498,117 | SH | DFND | 1 | 498,117 | 0 | 0 | |
| CELYAD SA | ADR | 151205200 | 1,791 | 75,920 | SH | DFND | 1 | 75,920 | 0 | 0 | |
| CHINA BIOLOGIC PRODS INC | COM | 16938C106 | 14,050 | 112,867 | SH | DFND | 1 | 112,867 | 0 | 0 | |
| CLEARSIDE BIOMEDICAL INC | COM | 185063104 | 34,496 | 1,988,208 | SH | DFND | 1 | 1,988,208 | 0 | 0 | |
| CLOVIS ONCOLOGY INC | COM | 189464100 | 23,433 | 650,000 | SH | DFND | 1 | 650,000 | 0 | 0 | |
| COHERUS BIOSCIENCES INC | COM | 19249H103 | 15,428 | 576,106 | SH | DFND | 1 | 576,106 | 0 | 0 | |
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | 8,773 | 455,515 | SH | DFND | 1 | 455,515 | 0 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 9,526 | 3,840,966 | SH | DFND | 1 | 3,840,966 | 0 | 0 | |
| CORBUS PHARMACEUTICALS HLDGS | COM | 21833P103 | 13,580 | 2,000,000 | SH | DFND | 1 | 2,000,000 | 0 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 3,522 | 214,132 | SH | DFND | 1 | 214,132 | 0 | 0 | |
| CURIS INC | COM | 231269101 | 6,292 | 2,410,900 | SH | DFND | 1 | 2,410,900 | 0 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 5,827 | 371,636 | SH | DFND | 1 | 371,636 | 0 | 0 | |
| DERMIRA INC | COM | 24983L104 | 5,820 | 172,083 | SH | DFND | 1 | 172,083 | 0 | 0 | |
| DEXCOM INC | COM | 252131107 | 8,766 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| EAGLE PHARMACEUTICALS INC | COM | 269796108 | 31,920 | 455,995 | SH | DFND | 1 | 455,995 | 0 | 0 | |
| EMERGENT BIOSOLUTIONS INC | COM | 29089Q105 | 7,883 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| EPIZYME INC | COM | 29428V104 | 1,570 | 159,513 | SH | DFND | 1 | 159,513 | 0 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 7,123 | 339,175 | SH | DFND | 1 | 339,175 | 0 | 0 | |
| FULGENT GENETICS INC | COM | 359664109 | 7,376 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| GALAPAGOS NV | SPON ADR | 36315X101 | 21,441 | 334,044 | SH | DFND | 1 | 334,044 | 0 | 0 | |
| GEMPHIRE THERAPEUTICS INC | COM | 36870A108 | 9,828 | 900,000 | SH | DFND | 1 | 900,000 | 0 | 0 | |
| GENVEC INC | COM NEW | 37246C307 | 468 | 1,015,685 | SH | DFND | 1 | 1,015,685 | 0 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 2,052 | 287,031 | SH | DFND | 1 | 287,031 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 30,519 | 1,771,263 | SH | DFND | 1 | 1,771,263 | 0 | 0 | |
| HTG MOLECULAR DIAGNOSTICS IN | COM | 40434H104 | 472 | 203,464 | SH | DFND | 1 | 203,464 | 0 | 0 | |
| IMMUNE DESIGN CORP | COM | 45252L103 | 3,282 | 432,990 | SH | DFND | 1 | 432,990 | 0 | 0 | |
| INC RESH HLDGS INC | CL A | 45329R109 | 8,916 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| INTEC PHARMA LTD JERUSALEM | SHS | M53644106 | 4,762 | 809,804 | SH | DFND | 1 | 809,804 | 0 | 0 | |
| INVUITY INC | COM NEW | 46187J205 | 10,530 | 767,466 | SH | DFND | 1 | 767,466 | 0 | 0 | |
| LION BIOTECHNOLOGIES INC | COM | 53619R102 | 4,164 | 505,941 | SH | DFND | 1 | 505,941 | 0 | 0 | |
| LIPOCINE INC NEW | COM | 53630X104 | 3,351 | 751,296 | SH | DFND | 1 | 751,296 | 0 | 0 | |
| MACROGENICS INC | COM | 556099109 | 21,176 | 707,978 | SH | DFND | 1 | 707,978 | 0 | 0 | |
| MINERVA NEUROSCIENCES INC | COM | 603380106 | 39,522 | 2,800,000 | SH | DFND | 1 | 2,800,000 | 0 | 0 | |
| MYOKARDIA INC | COM | 62857M105 | 26,239 | 1,605,790 | SH | DFND | 1 | 1,605,790 | 0 | 0 | |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 809 | 40,490 | SH | DFND | 1 | 40,490 | 0 | 0 | |
| NEOS THERAPEUTICS INC | COM | 64052L106 | 333 | 50,613 | SH | DFND | 1 | 50,613 | 0 | 0 | |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 20,170 | 398,301 | SH | DFND | 1 | 398,301 | 0 | 0 | |
| NEVRO CORP | COM | 64157F103 | 51,260 | 491,044 | SH | DFND | 1 | 491,044 | 0 | 0 | |
| OMEROS CORP | COM | 682143102 | 18,916 | 1,695,000 | SH | DFND | 1 | 1,695,000 | 0 | 0 | |
| ONCOBIOLOGICS INC | COM | 68235M105 | 4,366 | 1,027,216 | SH | DFND | 1 | 1,027,216 | 0 | 0 | |
| ONCOBIOLOGICS INC | *W EXP 02/18/201 | 68235M113 | 199 | 416,666 | SH | DFND | 1 | 416,666 | 0 | 0 | |
| ONCOBIOLOGICS INC | *W EXP 05/18/201 | 68235M121 | 500 | 416,666 | SH | DFND | 1 | 416,666 | 0 | 0 | |
| PFENEX INC | COM | 717071104 | 5,661 | 632,559 | SH | DFND | 1 | 632,559 | 0 | 0 | |
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 13,535 | 596,000 | SH | DFND | 1 | 596,000 | 0 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 16,904 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| PROTEOSTASIS THERAPEUTICS IN | COM | 74373B109 | 36,636 | 2,350,000 | SH | DFND | 1 | 2,350,000 | 0 | 0 | |
| PROVECTUS BIOPHARMACEUTICALS | *W EXP 06/19/202 | 74373P116 | 114 | 2,200,000 | SH | DFND | 1 | 2,200,000 | 0 | 0 | |
| PROVECTUS BIOPHARMACEUTICALS | COM | 74373P108 | 221 | 2,226,961 | SH | DFND | 1 | 2,226,961 | 0 | 0 | |
| QUOTIENT LTD | SHS | G73268107 | 21,800 | 2,787,717 | SH | DFND | 1 | 2,787,717 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 5,916 | 669,239 | SH | DFND | 1 | 669,239 | 0 | 0 | |
| REGENXBIO INC | COM | 75901B107 | 2,196 | 156,741 | SH | DFND | 1 | 156,741 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 4,241 | 1,155,600 | SH | DFND | 1 | 1,155,600 | 0 | 0 | |
| SANGAMO BIOSCIENCES INC | COM | 800677106 | 6,493 | 1,402,331 | SH | DFND | 1 | 1,402,331 | 0 | 0 | |
| SORRENTO THERAPEUTICS INC | COM NEW | 83587F202 | 16,417 | 2,121,013 | SH | DFND | 1 | 2,121,013 | 0 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 3,645 | 240,403 | SH | DFND | 1 | 240,403 | 0 | 0 | |
| THERAVANCE BIOPHARMA INC | COM | G8807B106 | 40,530 | 1,118,372 | SH | DFND | 1 | 1,118,372 | 0 | 0 | |
| THRESHOLD PHARMACEUTICAL INC | COM NEW | 885807206 | 686 | 1,012,255 | SH | DFND | 1 | 1,012,255 | 0 | 0 | |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 7,863 | 110,842 | SH | DFND | 1 | 110,842 | 0 | 0 | |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 16,492 | 507,907 | SH | DFND | 1 | 507,907 | 0 | 0 | |
| ZYNERBA PHARMACEUTICALS INC | COM | 98986X109 | 6,271 | 480,501 | SH | DFND | 1 | 480,501 | 0 | 0 | |