The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 5,278 200,000 SH   DFND 1 200,000 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 3,860 500,000 SH   DFND 1 500,000 0 0
ACLARIS THERAPEUTICS INC COM COM 00461U105 12,279 647,944 SH   DFND 1 647,944 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 203 25,000 SH   DFND 1 25,000 0 0
ADVAXIS INC COM NEW 007624208 7,224 800,000 SH   DFND 1 800,000 0 0
AGENUS INC COM NEW 00847G705 6,485 1,559,000 SH   DFND 1 1,559,000 0 0
AGILE THERAPEUTICS INC COM 00847L100 3,459 557,053 SH   DFND 1 557,053 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 36,673 1,497,475 SH   DFND 1 1,497,475 0 0
ALKERMES PLC SHS G01767105 23,933 700,000 SH   DFND 1 700,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 15,379 245,000 SH   DFND 1 245,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 1,268 150,000 SH   DFND 1 150,000 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 239 17,110 SH   DFND 1 17,110 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 3,179 1,081,867 SH   DFND 1 1,081,867 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 1,323 150,000 SH   DFND 1 150,000 0 0
ARDELYX INC COM 039697107 11,508 1,481,075 SH   DFND 1 1,481,075 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 1,141 61,500 SH   DFND 1 61,500 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 2,855 150,000 SH   DFND 1 150,000 0 0
AVEO PHARMACEUTICALS INC COM 053588109 1,001 1,087,715 SH   DFND 1 1,087,715 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 2,805 300,000 SH   DFND 1 300,000 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 3,056 1,080,000 SH   DFND 1 1,080,000 0 0
BIOTIE THERAPIES OYJ SPONSORED ADR 09074D103 1,320 50,000 SH   DFND 1 50,000 0 0
CELATOR PHARMACEUTICALS INC COM 15089R102 6,839 620,000 SH   DFND 1 620,000 0 0
CELGENE CORP COM 151020104 10,009 100,000 SH   DFND 1 100,000 0 0
CELLECTAR BIOSCIENCES INC COM 15117F302 180 52,999 SH   DFND 1 52,999 0 0
CELLECTAR BIOSCIENCES INC *W EXP 08/19/201 15117F112 38 52,999 SH   DFND 1 52,999 0 0
CELLECTIS S A SPONSORED ADS 15117K103 12,901 469,145 SH   DFND 1 469,145 0 0
CELYAD SA ADR 151205200 3,312 75,000 SH   DFND 1 75,000 0 0
CHINA BIOLOGIC PRODS INC COM 16938C106 12,765 111,500 SH   DFND 1 111,500 0 0
COHERUS BIOSCIENCES INC COM 19249H103 12,083 569,130 SH   DFND 1 569,130 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 8,168 450,000 SH   DFND 1 450,000 0 0
CONTRAFECT CORP COM 212326102 2,837 834,406 SH   DFND 1 834,406 0 0
CURIS INC COM 231269101 1,871 1,162,400 SH   DFND 1 1,162,400 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 4,786 371,023 SH   DFND 1 371,023 0 0
DERMIRA INC COM 24983L104 3,516 170,000 SH   DFND 1 170,000 0 0
DEXCOM INC COM 252131107 10,390 153,000 SH   DFND 1 153,000 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 18,759 975,000 SH   DFND 1 975,000 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 20,250 500,000 SH   DFND 1 500,000 0 0
EPIRUS BIOPHARMACEUTICALS IN COM 29428P107 2,412 896,600 SH   DFND 1 896,600 0 0
EPIZYME INC COM 29428V104 3,227 266,250 SH   DFND 1 266,250 0 0
FORWARD PHARMA A/S SPONSORED ADR 34986J105 5,696 335,068 SH   DFND 1 335,068 0 0
GENVEC INC COM NEW 37246C307 948 1,176,235 SH   DFND 1 1,176,235 0 0
GLYCOMIMETICS INC COM 38000Q102 1,690 283,555 SH   DFND 1 283,555 0 0
HERON THERAPEUTICS INC COM 427746102 33,233 1,750,000 SH   DFND 1 1,750,000 0 0
HTG MOLECULAR DIAGNOSTICS IN COM 40434H104 577 201,000 SH   DFND 1 201,000 0 0
IMMUNE DESIGN CORP COM 45252L103 2,457 189,000 SH   DFND 1 189,000 0 0
INTEC PHARMA LTD JERUSALEM SHS M53644106 3,296 800,000 SH   DFND 1 800,000 0 0
KITE PHARMA INC COM 49803L109 3,159 68,800 SH   DFND 1 68,800 0 0
LION BIOTECHNOLOGIES INC COM 53619R102 2,539 499,815 SH   DFND 1 499,815 0 0
LIPOCINE INC NEW COM 53630X104 6,767 666,666 SH   DFND 1 666,666 0 0
MACROGENICS INC COM 556099109 13,125 700,000 SH   DFND 1 700,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 10,763 1,752,946 SH   DFND 1 1,752,946 0 0
MIRATI THERAPEUTICS INC COM 60468T105 10,601 495,356 SH   DFND 1 495,356 0 0
MYOKARDIA INC COM 62857M105 8,069 753,388 SH   DFND 1 753,388 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 609 40,000 SH   DFND 1 40,000 0 0
NEKTAR THERAPEUTICS COM 640268108 27,500 2,000,000 SH   DFND 1 2,000,000 0 0
NEOS THERAPEUTICS INC COM 64052L106 540 50,000 SH   DFND 1 50,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 23,884 603,900 SH   DFND 1 603,900 0 0
NEVRO CORP COM 64157F103 27,308 485,386 SH   DFND 1 485,386 0 0
NOVAVAX INC COM 670002104 8,256 1,600,000 SH   DFND 1 1,600,000 0 0
OMEROS CORP COM 682143102 30,066 1,960,000 SH   DFND 1 1,960,000 0 0
OVASCIENCE INC COM 69014Q101 2,393 252,180 SH   DFND 1 252,180 0 0
PFENEX INC COM 717071104 6,143 624,900 SH   DFND 1 624,900 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 14,280 700,000 SH   DFND 1 700,000 0 0
PRONAI THERAPEUTICS INC COM 74346L101 358 53,153 SH   DFND 1 53,153 0 0
PROTEOSTASIS THERAPEUTICS IN COM 74373B109 16,644 1,726,599 SH   DFND 1 1,726,599 0 0
PROVECTUS BIOPHARMACEUTICALS *W EXP 06/19/202 74373P116 440 2,200,000 SH   DFND 1 2,200,000 0 0
PROVECTUS BIOPHARMACEUTICALS COM 74373P108 836 2,200,000 SH   DFND 1 2,200,000 0 0
QUOTIENT LTD SHS G73268107 13,368 1,519,100 SH   DFND 1 1,519,100 0 0
RECRO PHARMA INC COM 75629F109 4,657 780,000 SH   DFND 1 780,000 0 0
REGENXBIO INC COM 75901B107 1,693 156,741 SH   DFND 1 156,741 0 0
REGULUS THERAPEUTICS INC COM 75915K101 212 30,656 SH   DFND 1 30,656 0 0
ROCKWELL MEDICAL INC COM 774374102 8,299 1,105,000 SH   DFND 1 1,105,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 30,297 945,000 SH   DFND 1 945,000 0 0
SERES THERAPEUTICS INC COM 81750R102 6,640 250,000 SH   DFND 1 250,000 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 11,273 2,095,334 SH   DFND 1 2,095,334 0 0
SYNDAX PHARMACEUTICALS INC. COM 87164F105 2,856 214,419 SH   DFND 1 259,581 0 0
TESARO INC COM 881569107 12,824 291,250 SH   DFND 1 291,250 0 0
TETRALOGIC PHARMACEUTICALS C NOTE 8.000% 6/1 88165UAB5 1,150 5,000,000 SH   DFND 1 5,000,000 0 0
THRESHOLD PHARMACEUTICALS INC COM NEW 885807206 460 1,000,000 SH   DFND 1 1,000,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 6,932 109,500 SH   DFND 1 109,500 0 0
VERACYTE INC COM 92337F107 745 137,990 SH   DFND 1 137,990 0 0
VITAE PHARMACEUTICALS INC COM 92847N103 11,503 1,735,000 SH   DFND 1 1,735,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 5,442 392,079 SH   DFND 1 392,079 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 4,489 475,035 SH   DFND 1 475,035 0 0