The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 9,752 200,000 SH   DFND 1 200,000 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 5,395 500,000 SH   DFND 1 500,000 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 17,456 647,944 SH   DFND 1 647,944 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 302 25,000 SH   DFND 1 25,000 0 0
ADVAXIS INC COM NEW 007624208 8,048 800,000 SH   DFND 1 800,000 0 0
AGENUS INC COM NEW 00847G705 7,078 1,559,000 SH   DFND 1 1,559,000 0 0
AGILE THERAPEUTICS INC COM 00847L100 1,777 182,053 SH   DFND 1 182,053 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 25,019 757,475 SH   DFND 1 757,475 0 0
ALKERMES PLC SHS G01767105 55,566 700,000 SH   DFND 1 700,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 23,064 245,000 SH   DFND 1 245,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109 1,455 150,000 SH   DFND 1 150,000 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 349 17,110 SH   DFND 1 17,110 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 2,737 1,081,867 SH   DFND 1 1,081,867 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 1,872 150,000 SH   DFND 1 150,000 0 0
ARDELYX INC COM 039697107 26,837 1,481,075 SH   DFND 1 1,481,075 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 1,127 61,500 SH   DFND 1 61,500 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 3,962 150,000 SH   DFND 1 150,000 0 0
AVEO PHARMACEUTICALS INC COM 053588109 1,371 1,087,715 SH   DFND 1 1,087,715 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 6,081 300,000 SH   DFND 1 300,000 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 11,146 1,080,000 SH   DFND 1 1,080,000 0 0
BIOTIE THERAPIES OYJ SPONSORED ADR 09074D103 718 50,000 SH   DFND 1 50,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2,634 100,000 SH   DFND 1 100,000 0 0
CELLECTAR BIOSCIENCES INC COM NEW 15117F203 390 530,000 SH   DFND 1 530,000 0 0
CELLECTAR BIOSCIENCES INC *W EXP 08/19/201 15117F112 296 530,000 SH   DFND 1 530,000 0 0
CELLECTIS SA SPONSORED ADS 15117K103 14,558 469,145 SH   DFND 1 469,145 0 0
CELYAD SA ADR 151205200 4,094 75,000 SH   DFND 1 75,000 0 0
CHINA BIOLOGIC PRODUCTS INC COM 16938C106 15,884 111,500 SH   DFND 1 111,500 0 0
COHERUS BIOSCIENCES INC COM 19249H103 13,067 569,130 SH   DFND 1 569,130 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 12,375 450,000 SH   DFND 1 450,000 0 0
CONTRAFECT CORP COM 212326102 1,113 234,406 SH   DFND 1 234,406 0 0
CURIS INC COM 231269101 3,383 1,162,400 SH   DFND 1 1,162,400 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 7,743 371,023 SH   DFND 1 371,023 0 0
DERMIRA INC COM 24983L104 5,884 170,000 SH   DFND 1 170,000 0 0
DEXCOM INC COM 252131107 12,531 153,000 SH   DFND 1 153,000 0 0
DYAX CORP COM 26746E103 52,668 1,400,000 SH   DFND 1 1,400,000 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 13,892 575,000 SH   DFND 1 575,000 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 35,468 400,000 SH   DFND 1 400,000 0 0
EPIRUS BIOPHARMACEUTICALS IN COM 29428P107 2,770 896,600 SH   DFND 1 896,600 0 0
EPIZYME INC COM 29428V104 4,265 266,250 SH   DFND 1 266,250 0 0
FORWARD PHARMA A/S SPONSORED ADR 34986J105 6,366 335,068 SH   DFND 1 335,068 0 0
GENVEC INC COM NEW 37246C307 2,164 1,176,235 SH   DFND 1 1,176,235 0 0
GLYCOMIMETICS INC COM 38000Q102 1,622 283,555 SH   DFND 1 283,555 0 0
HERON THERAPEUTICS INC COM 427746102 45,009 1,685,719 SH   DFND 1 1,685,719 0 0
HTG MOLECULAR DIAGNOSTICS COM 40434H104 876 201,000 SH   DFND 1 201,000 0 0
IMMUNE DESIGN CORP COM 45252L103 3,795 189,000 SH   DFND 1 189,000 0 0
INTEC PHARMA LTD SHS M53644106 4,288 800,000 SH   DFND 1 800,000 0 0
KITE PHARMA INC COM 49803L109 4,239 68,800 SH   DFND 1 68,800 0 0
LION BIOTECHNOLOGIES INC COM 53619R102 3,859 499,815 SH   DFND 1 499,815 0 0
LIPOCINE INC COM 53630X104 8,620 666,666 SH   DFND 1 666,666 0 0
MACROGENICS INC COM 556099109 15,485 500,000 SH   DFND 1 500,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 6,950 1,145,043 SH   DFND 1 1,145,043 0 0
MIRATI THERAPEUTICS INC COM 60468T105 15,653 495,356 SH   DFND 1 495,356 0 0
MYOKARDIA INC COM 62857M105 11,045 753,388 SH   DFND 1 753,388 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 588 40,000 SH   DFND 1 40,000 0 0
NEKTAR THERAPEUTICS COM 640268108 12,893 765,156 SH   DFND 1 765,156 0 0
NEOS THERAPEUTICS INC COM 64052L106 716 50,000 SH   DFND 1 50,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 34,163 603,900 SH   DFND 1 603,900 0 0
NEVRO CORP COM 64157F103 17,916 265,386 SH   DFND 1 265,386 0 0
NOVAVAX INC COM 670002104 13,424 1,600,000 SH   DFND 1 1,600,000 0 0
OMEROS CORP COM 682143102 30,831 1,960,000 SH   DFND 1 1,960,000 0 0
OVASCIENCE INC COM 69014Q101 2,464 252,180 SH   DFND 1 252,180 0 0
PFENEX INC COM 717071104 7,736 624,900 SH   DFND 1 624,900 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 25,725 500,000 SH   DFND 1 500,000 0 0
PRONAI THERAPEUTICS INC COM 74346L101 799 53,153 SH   DFND 1 53,153 0 0
PROVECTUS BIOPHARMACEUTICALS *W EXP 06/24/202 74373P116 550 2,200,000 SH   DFND 1 2,200,000 0 0
PROVECTUS BIOPHARMACEUTICALS COM 74373P108 858 2,200,000 SH   DFND 1 2,200,000 0 0
QUOTIENT LTD SHS G73268107 24,306 1,519,100 SH   DFND 1 1,519,100 0 0
RECRO PHARMA INC COM 75629F109 7,020 780,000 SH   DFND 1 780,000 0 0
REGENXBIO INC COM 75901B107 2,602 156,741 SH   DFND 1 156,741 0 0
REGULUS THERAPEUTICS INC COM 75915K101 267 30,656 SH   DFND 1 30,656 0 0
ROCKWELL MEDICAL INC COM 774374102 11,315 1,105,000 SH   DFND 1 1,105,000 0 0
SAGE THERAPEUTICS INC COM 78667J108 18,365 315,000 SH   DFND 1 315,000 0 0
SERES THERAPEUTICS INC COM 81750R102 8,773 250,000 SH   DFND 1 250,000 0 0
SORRENTO THERAPEUTICS INC COM NEW 83587F202 18,250 2,095,334 SH   DFND 1 2,095,334 0 0
TESARO INC COM 881569107 15,238 291,250 SH   DFND 1 291,250 0 0
TETRALOGIC PHARMACEUTICALS C NOTE 8.000% 6/1 88165UAB5 2,078 5,000,000 SH   DFND 1 5,000,000 0 0
THRESHOLD PHARMACEUTICALS INC COM NEW 885807206 480 1,000,000 SH   DFND 1 1,000,000 0 0
ULTRAGENYX PHARMACEUTICAL INC COM 90400D108 12,284 109,500 SH   DFND 1 109,500 0 0
VERACYTE INC COM 92337F107 994 137,990 SH   DFND 1 137,990 0 0
VITAE PHARMACEUTICALS INC COM 92847N103 11,284 623,409 SH   DFND 1 623,409 0 0
WAVE LIFE SCIENCES PTE LTD SHS Y95308105 6,254 392,079 SH   DFND 1 392,079 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 3,591 356,600 SH   DFND 1 356,600 0 0