The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 7,299 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| ACELRX PHARMACEUTICALS INC | COM | 00444T100 | 9,008 | 750,000 | SH | DFND | 1 | 750,000 | 0 | 0 | |
| AGENUS INC | COM NEW | 00847G705 | 3,170 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| ALKERMES PLC | SHS | G01767105 | 8,818 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 3,357 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| AQUINOX PHARMACEUTICALS INC | COM | 03842B101 | 3,143 | 246,877 | SH | DFND | 1 | 246,877 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 8,225 | 1,750,000 | SH | DFND | 1 | 1,750,000 | 0 | 0 | |
| ARROWHEAD RESEARCH CORP | COM NEW | 042797209 | 16,420 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| AUSPEX PHARMACEUTICALS INC | COM | 05211J102 | 3,076 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 | 12,357 | 1,168,000 | SH | DFND | 1 | 1,168,000 | 0 | 0 | |
| BIOGEN IDEC INC | COM | 09062X103 | 3,059 | 10,000 | SH | DFND | 1 | 10,000 | 0 | 0 | |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 20,463 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| CELSUS THERAPEUTICS PLC | SPONSORED ADR NE | 15119A202 | 668 | 103,000 | SH | DFND | 1 | 103,000 | 0 | 0 | |
| CHIMERIX INC | COM | 16934W106 | 6,852 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| CLOVIS ONCOLOGY INC | COM | 189464100 | 8,312 | 120,000 | SH | DFND | 1 | 120,000 | 0 | 0 | |
| CUBIST PHARMACEUTICALS INC | COM | 229678107 | 21,945 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| DEXCOM INC | COM | 252131107 | 12,408 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| DYAX CORP | COM | 26746E103 | 17,960 | 2,000,000 | SH | DFND | 1 | 2,000,000 | 0 | 0 | |
| EAGLE PHARMACEUTICALS INC | COM | 269796108 | 5,100 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| GALECTIN THERAPEUTICS INC | COM NEW | 363225202 | 5,328 | 348,000 | SH | DFND | 1 | 348,000 | 0 | 0 | |
| GENVEC INC | COM NEW | 37246C307 | 3,523 | 1,329,300 | SH | DFND | 1 | 1,329,300 | 0 | 0 | |
| GERON CORP | COM | 374163103 | 3,135 | 1,500,000 | SH | DFND | 1 | 1,500,000 | 0 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 7,665 | 469,400 | SH | DFND | 1 | 469,400 | 0 | 0 | |
| IDENIX PHARMACEUTICALS INC | COM | 45166R204 | 15,075 | 2,500,000 | SH | DFND | 1 | 2,500,000 | 0 | 0 | |
| IDERA PHARMACEUTICALS INC | COM NEW | 45168K306 | 1,632 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 16,490 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 13,868 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| KARYOPHARM THERAPEUTICS INC | COM | 48576U106 | 8,649 | 280,000 | SH | DFND | 1 | 280,000 | 0 | 0 | |
| MEDIVATION INC | COM | 58501N101 | 38,622 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| MERCK & CO. INC NEW | COM | 58933Y105 | 11,354 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 8,260 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| NOVAVAX INC | COM | 670002104 | 4,530 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| OMEROS CORP | COM | 682143102 | 6,035 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| PACIRA PHARMACEUTICALS INC | COM | 695127100 | 3,500 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 5,180 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| PROTHENA CORP PLC | SHS | G72800108 | 13,409 | 350,000 | SH | DFND | 1 | 350,000 | 0 | 0 | |
| PTC THERAPEUTICS INC | COM | 69366J200 | 14,377 | 550,000 | SH | DFND | 1 | 550,000 | 0 | 0 | |
| PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 21,609 | 207,500 | SH | DFND | 1 | 207,500 | 0 | 0 | |
| RECEPTOS INC | COM | 756207106 | 18,873 | 450,000 | SH | DFND | 1 | 450,000 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 3,660 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| REGULUS THERAPEUTICS INC | COM | 75915K101 | 1,804 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| ROCKWELL MED INC | COM | 774374102 | 5,064 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| SANGAMO BIOSCIENCES INC | COM | 800677106 | 10,848 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| SORRENTO THERAPEUTICS INC | COM NEW | 83587F202 | 8,974 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| TESARO INC | COM | 881569107 | 8,844 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 2,933 | 60,000 | SH | DFND | 1 | 60,000 | 0 | 0 | |