Accounting for Share-Based Payments - Stock-Based Compensation (Details) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Accounting for Shared-Based Payments
Total stock-based compensation expense	$ 4,668,815	$ 2,379,360
General and administrative
Accounting for Shared-Based Payments
Total stock-based compensation expense	3,267,349	1,798,288
Research and development
Accounting for Shared-Based Payments
Total stock-based compensation expense	$ 1,401,466	$ 581,072