3.22.1 html 202 301 1 false 57 0 false 6 false false R1.htm 0001001 - Document - Cover Page Sheet http://www.hepion.com/role/CoverPage Cover Page Cover 1 false false R2.htm 0002002 - Document - Audit Information Sheet http://www.hepion.com/role/AuditInformation Audit Information Notes 2 false false R3.htm 1001003 - Statement - Consolidated Balance Sheets Sheet http://www.hepion.com/role/ConsolidatedBalanceSheets Consolidated Balance Sheets Uncategorized 3 false false R4.htm 1002004 - Statement - Consolidated Balance Sheets (Parenthetical) Sheet http://www.hepion.com/role/ConsolidatedBalanceSheetsParenthetical Consolidated Balance Sheets (Parenthetical) Cover 4 false false R5.htm 1003005 - Statement - Consolidated Statements of Operations and Comprehensive Loss Sheet http://www.hepion.com/role/ConsolidatedStatementsofOperationsandComprehensiveLoss Consolidated Statements of Operations and Comprehensive Loss Statements 5 false false R6.htm 1004006 - Statement - Consolidated Statements of Changes in Stockholders??? Equity Sheet http://www.hepion.com/role/ConsolidatedStatementsofChangesinStockholdersEquity Consolidated Statements of Changes in Stockholders??? Equity Statements 6 false false R7.htm 1005007 - Statement - Consolidated Statements of Cash Flows Sheet http://www.hepion.com/role/ConsolidatedStatementsofCashFlows Consolidated Statements of Cash Flows Statements 7 false false R8.htm 2101101 - Disclosure - Business Overview Sheet http://www.hepion.com/role/BusinessOverview Business Overview Notes 8 false false R9.htm 2103102 - Disclosure - Basis of Presentation Sheet http://www.hepion.com/role/BasisofPresentation Basis of Presentation Notes 9 false false R10.htm 2108103 - Disclosure - Summary of Significant Accounting Policies Sheet http://www.hepion.com/role/SummaryofSignificantAccountingPolicies Summary of Significant Accounting Policies Notes 10 false false R11.htm 2116104 - Disclosure - Recent Accounting Pronouncements Sheet http://www.hepion.com/role/RecentAccountingPronouncements Recent Accounting Pronouncements Notes 11 false false R12.htm 2118105 - Disclosure - Stockholders' Equity and Derivative Liability - Warrants Sheet http://www.hepion.com/role/StockholdersEquityandDerivativeLiabilityWarrants Stockholders' Equity and Derivative Liability - Warrants Notes 12 false false R13.htm 2124106 - Disclosure - Fair Value Measurements Sheet http://www.hepion.com/role/FairValueMeasurements Fair Value Measurements Notes 13 false false R14.htm 2130107 - Disclosure - Indefinite-lived Intangible Assets, Goodwill, and Property and Equipment Sheet http://www.hepion.com/role/IndefinitelivedIntangibleAssetsGoodwillandPropertyandEquipment Indefinite-lived Intangible Assets, Goodwill, and Property and Equipment Notes 14 false false R15.htm 2135108 - Disclosure - Accrued Liabilities Sheet http://www.hepion.com/role/AccruedLiabilities Accrued Liabilities Notes 15 false false R16.htm 2138109 - Disclosure - Accounting for Share-Based Payments Sheet http://www.hepion.com/role/AccountingforShareBasedPayments Accounting for Share-Based Payments Notes 16 false false R17.htm 2144110 - Disclosure - Income Taxes Sheet http://www.hepion.com/role/IncomeTaxes Income Taxes Notes 17 false false R18.htm 2149111 - Disclosure - Loss per Share Sheet http://www.hepion.com/role/LossperShare Loss per Share Notes 18 false false R19.htm 2153112 - Disclosure - Commitments and Contingencies Sheet http://www.hepion.com/role/CommitmentsandContingencies Commitments and Contingencies Notes 19 false false R20.htm 2157113 - Disclosure - Subsequent Events Sheet http://www.hepion.com/role/SubsequentEvents Subsequent Events Notes 20 false false R21.htm 2209201 - Disclosure - Summary of Significant Accounting Policies (Policies) Sheet http://www.hepion.com/role/SummaryofSignificantAccountingPoliciesPolicies Summary of Significant Accounting Policies (Policies) Policies http://www.hepion.com/role/SummaryofSignificantAccountingPolicies 21 false false R22.htm 2304301 - Disclosure - Basis of Presentation (Tables) Sheet http://www.hepion.com/role/BasisofPresentationTables Basis of Presentation (Tables) Tables http://www.hepion.com/role/BasisofPresentation 22 false false R23.htm 2319302 - Disclosure - Stockholder???s Equity and Derivative Liability - Warrants (Tables) Sheet http://www.hepion.com/role/StockholdersEquityandDerivativeLiabilityWarrantsTables Stockholder???s Equity and Derivative Liability - Warrants (Tables) Tables 23 false false R24.htm 2325303 - Disclosure - Fair Value Measurements (Tables) Sheet http://www.hepion.com/role/FairValueMeasurementsTables Fair Value Measurements (Tables) Tables http://www.hepion.com/role/FairValueMeasurements 24 false false R25.htm 2331304 - Disclosure - Indefinite-lived Intangible Assets, Goodwill, and Property and Equipment (Tables) Sheet http://www.hepion.com/role/IndefinitelivedIntangibleAssetsGoodwillandPropertyandEquipmentTables Indefinite-lived Intangible Assets, Goodwill, and Property and Equipment (Tables) Tables http://www.hepion.com/role/IndefinitelivedIntangibleAssetsGoodwillandPropertyandEquipment 25 false false R26.htm 2336305 - Disclosure - Accrued Liabilities (Tables) Sheet http://www.hepion.com/role/AccruedLiabilitiesTables Accrued Liabilities (Tables) Tables http://www.hepion.com/role/AccruedLiabilities 26 false false R27.htm 2339306 - Disclosure - Accounting for Share-Based Payments (Tables) Sheet http://www.hepion.com/role/AccountingforShareBasedPaymentsTables Accounting for Share-Based Payments (Tables) Tables http://www.hepion.com/role/AccountingforShareBasedPayments 27 false false R28.htm 2345307 - Disclosure - Income Taxes (Tables) Sheet http://www.hepion.com/role/IncomeTaxesTables Income Taxes (Tables) Tables http://www.hepion.com/role/IncomeTaxes 28 false false R29.htm 2350308 - Disclosure - Loss per Share (Tables) Sheet http://www.hepion.com/role/LossperShareTables Loss per Share (Tables) Tables http://www.hepion.com/role/LossperShare 29 false false R30.htm 2354309 - Disclosure - Commitments and Contingencies (Tables) Sheet http://www.hepion.com/role/CommitmentsandContingenciesTables Commitments and Contingencies (Tables) Tables http://www.hepion.com/role/CommitmentsandContingencies 30 false false R31.htm 2402401 - Disclosure - Business Overview (Details) Sheet http://www.hepion.com/role/BusinessOverviewDetails Business Overview (Details) Details http://www.hepion.com/role/BusinessOverview 31 false false R32.htm 2405402 - Disclosure - Basis of Presentation - Warrants Corrections (Details) Sheet http://www.hepion.com/role/BasisofPresentationWarrantsCorrectionsDetails Basis of Presentation - Warrants Corrections (Details) Details 32 false false R33.htm 2406403 - Disclosure - Basis of Presentation - Note disclosures affected by corrections (Details) Sheet http://www.hepion.com/role/BasisofPresentationNotedisclosuresaffectedbycorrectionsDetails Basis of Presentation - Note disclosures affected by corrections (Details) Details 33 false false R34.htm 2407404 - Disclosure - Basis of Presentation - Additional Information (Details) Sheet http://www.hepion.com/role/BasisofPresentationAdditionalInformationDetails Basis of Presentation - Additional Information (Details) Details 34 false false R35.htm 2410405 - Disclosure - Summary of Significant Accounting Policies - Cash (Details) Sheet http://www.hepion.com/role/SummaryofSignificantAccountingPoliciesCashDetails Summary of Significant Accounting Policies - Cash (Details) Details http://www.hepion.com/role/SummaryofSignificantAccountingPoliciesPolicies 35 false false R36.htm 2411406 - Disclosure - Summary of Significant Accounting Policies - Derivative Financial Instruments (Details) Sheet http://www.hepion.com/role/SummaryofSignificantAccountingPoliciesDerivativeFinancialInstrumentsDetails Summary of Significant Accounting Policies - Derivative Financial Instruments (Details) Details 36 false false R37.htm 2412407 - Disclosure - Summary of Significant Accounting Policies - Property, equipment and depreciation (Details) Sheet http://www.hepion.com/role/SummaryofSignificantAccountingPoliciesPropertyequipmentanddepreciationDetails Summary of Significant Accounting Policies - Property, equipment and depreciation (Details) Details 37 false false R38.htm 2413408 - Disclosure - Summary of Significant Accounting Policies - Goodwill and In-Process Research and Development (Details) Sheet http://www.hepion.com/role/SummaryofSignificantAccountingPoliciesGoodwillandInProcessResearchandDevelopmentDetails Summary of Significant Accounting Policies - Goodwill and In-Process Research and Development (Details) Details 38 false false R39.htm 2414409 - Disclosure - Summary of Significant Accounting Policies - Research and Development (Details) Sheet http://www.hepion.com/role/SummaryofSignificantAccountingPoliciesResearchandDevelopmentDetails Summary of Significant Accounting Policies - Research and Development (Details) Details 39 false false R40.htm 2415410 - Disclosure - Summary of Significant Accounting Policies - Segment Information (Details) Sheet http://www.hepion.com/role/SummaryofSignificantAccountingPoliciesSegmentInformationDetails Summary of Significant Accounting Policies - Segment Information (Details) Details 40 false false R41.htm 2417411 - Disclosure - Recent Accounting Pronouncements - Accounting Standards Update (Details) Sheet http://www.hepion.com/role/RecentAccountingPronouncementsAccountingStandardsUpdateDetails Recent Accounting Pronouncements - Accounting Standards Update (Details) Details 41 false false R42.htm 2420412 - Disclosure - Stockholders' Equity and Derivative Liability - Warrants - Series A Convertible Preferred Stock (Details) Sheet http://www.hepion.com/role/StockholdersEquityandDerivativeLiabilityWarrantsSeriesAConvertiblePreferredStockDetails Stockholders' Equity and Derivative Liability - Warrants - Series A Convertible Preferred Stock (Details) Details 42 false false R43.htm 2421413 - Disclosure - Stockholders' Equity and Derivative Liability - Warrants - Series C Convertible Preferred Stock Issuance (Details) Sheet http://www.hepion.com/role/StockholdersEquityandDerivativeLiabilityWarrantsSeriesCConvertiblePreferredStockIssuanceDetails Stockholders' Equity and Derivative Liability - Warrants - Series C Convertible Preferred Stock Issuance (Details) Details 43 false false R44.htm 2422414 - Disclosure - Stockholders' Equity and Derivative Liability - Warrants - Components of changes (Details) Sheet http://www.hepion.com/role/StockholdersEquityandDerivativeLiabilityWarrantsComponentsofchangesDetails Stockholders' Equity and Derivative Liability - Warrants - Components of changes (Details) Details 44 false false R45.htm 2423415 - Disclosure - Stockholders' Equity and Derivative Liability - Warrants - Common Stock Offering (Details) Sheet http://www.hepion.com/role/StockholdersEquityandDerivativeLiabilityWarrantsCommonStockOfferingDetails Stockholders' Equity and Derivative Liability - Warrants - Common Stock Offering (Details) Details 45 false false R46.htm 2426416 - Disclosure - Fair Value Measurements - Schedule of Liabilities Measured on Recurring Basis (Details) Sheet http://www.hepion.com/role/FairValueMeasurementsScheduleofLiabilitiesMeasuredonRecurringBasisDetails Fair Value Measurements - Schedule of Liabilities Measured on Recurring Basis (Details) Details 46 false false R47.htm 2427417 - Disclosure - Fair Value Measurements - Additional Information (Details) Sheet http://www.hepion.com/role/FairValueMeasurementsAdditionalInformationDetails Fair Value Measurements - Additional Information (Details) Details 47 false false R48.htm 2428418 - Disclosure - Fair Value Measurements - Assumptions Used to Calculate Fair Value (Details) Sheet http://www.hepion.com/role/FairValueMeasurementsAssumptionsUsedtoCalculateFairValueDetails Fair Value Measurements - Assumptions Used to Calculate Fair Value (Details) Details 48 false false R49.htm 2429419 - Disclosure - Fair Value Measurements - Activity for Fair Value of Contingent Consideration (Details) Sheet http://www.hepion.com/role/FairValueMeasurementsActivityforFairValueofContingentConsiderationDetails Fair Value Measurements - Activity for Fair Value of Contingent Consideration (Details) Details 49 false false R50.htm 2432420 - Disclosure - Indefinite-lived Intangible Assets, Goodwill, and Property and Equipment - IPR&D (Details) Sheet http://www.hepion.com/role/IndefinitelivedIntangibleAssetsGoodwillandPropertyandEquipmentIPRDDetails Indefinite-lived Intangible Assets, Goodwill, and Property and Equipment - IPR&D (Details) Details http://www.hepion.com/role/IndefinitelivedIntangibleAssetsGoodwillandPropertyandEquipmentTables 50 false false R51.htm 2433421 - Disclosure - Indefinite-lived Intangible Assets, Goodwill, and Property and Equipment - Goodwill (Details) Sheet http://www.hepion.com/role/IndefinitelivedIntangibleAssetsGoodwillandPropertyandEquipmentGoodwillDetails Indefinite-lived Intangible Assets, Goodwill, and Property and Equipment - Goodwill (Details) Details http://www.hepion.com/role/IndefinitelivedIntangibleAssetsGoodwillandPropertyandEquipmentTables 51 false false R52.htm 2434422 - Disclosure - Indefinite-lived Intangible Assets, Goodwill, and Property and Equipment - PPE (Details) Sheet http://www.hepion.com/role/IndefinitelivedIntangibleAssetsGoodwillandPropertyandEquipmentPPEDetails Indefinite-lived Intangible Assets, Goodwill, and Property and Equipment - PPE (Details) Details http://www.hepion.com/role/IndefinitelivedIntangibleAssetsGoodwillandPropertyandEquipmentTables 52 false false R53.htm 2437423 - Disclosure - Accrued Liabilities (Details) Sheet http://www.hepion.com/role/AccruedLiabilitiesDetails Accrued Liabilities (Details) Details http://www.hepion.com/role/AccruedLiabilitiesTables 53 false false R54.htm 2440424 - Disclosure - Accounting for Share-Based Payments - Additional Information (Details) Sheet http://www.hepion.com/role/AccountingforShareBasedPaymentsAdditionalInformationDetails Accounting for Share-Based Payments - Additional Information (Details) Details 54 false false R55.htm 2441425 - Disclosure - Accounting for Share-Based Payments - Stock-Based Compensation (Details) Sheet http://www.hepion.com/role/AccountingforShareBasedPaymentsStockBasedCompensationDetails Accounting for Share-Based Payments - Stock-Based Compensation (Details) Details 55 false false R56.htm 2442426 - Disclosure - Accounting for Share-Based Payments - Stock Option Activity (Details) Sheet http://www.hepion.com/role/AccountingforShareBasedPaymentsStockOptionActivityDetails Accounting for Share-Based Payments - Stock Option Activity (Details) Details 56 false false R57.htm 2443427 - Disclosure - Accounting for Share-Based Payments - Weighted-Average Assumptions Used Black Scholes Model (Details) Sheet http://www.hepion.com/role/AccountingforShareBasedPaymentsWeightedAverageAssumptionsUsedBlackScholesModelDetails Accounting for Share-Based Payments - Weighted-Average Assumptions Used Black Scholes Model (Details) Details 57 false false R58.htm 2446428 - Disclosure - Income Taxes - Additional Information (Details) Sheet http://www.hepion.com/role/IncomeTaxesAdditionalInformationDetails Income Taxes - Additional Information (Details) Details 58 false false R59.htm 2447429 - Disclosure - Income Taxes - Deferred Tax Assets and Liabilities (Details) Sheet http://www.hepion.com/role/IncomeTaxesDeferredTaxAssetsandLiabilitiesDetails Income Taxes - Deferred Tax Assets and Liabilities (Details) Details 59 false false R60.htm 2448430 - Disclosure - Income Taxes - Reconciliation of Income Tax Benefit (Details) Sheet http://www.hepion.com/role/IncomeTaxesReconciliationofIncomeTaxBenefitDetails Income Taxes - Reconciliation of Income Tax Benefit (Details) Details 60 false false R61.htm 2451431 - Disclosure - Loss per Share - Computation of Basic and Diluted Net Loss Per Share (Details) Sheet http://www.hepion.com/role/LossperShareComputationofBasicandDilutedNetLossPerShareDetails Loss per Share - Computation of Basic and Diluted Net Loss Per Share (Details) Details 61 false false R62.htm 2452432 - Disclosure - Loss per Share - Schedule of Outstanding Securities Excluded from Computation of Basic and Diluted Weighted Shares Outstanding (Details) Sheet http://www.hepion.com/role/LossperShareScheduleofOutstandingSecuritiesExcludedfromComputationofBasicandDilutedWeightedSharesOutstandingDetails Loss per Share - Schedule of Outstanding Securities Excluded from Computation of Basic and Diluted Weighted Shares Outstanding (Details) Details 62 false false R63.htm 2455433 - Disclosure - Commitments and Contingencies - Additional Information (Details) Sheet http://www.hepion.com/role/CommitmentsandContingenciesAdditionalInformationDetails Commitments and Contingencies - Additional Information (Details) Details 63 false false R64.htm 2456434 - Disclosure - Commitments and Contingencies - Future Minimum Rental Payments Under the Company's Noncancelable Operating Leases (Details) Sheet http://www.hepion.com/role/CommitmentsandContingenciesFutureMinimumRentalPaymentsUndertheCompanysNoncancelableOperatingLeasesDetails Commitments and Contingencies - Future Minimum Rental Payments Under the Company's Noncancelable Operating Leases (Details) Details 64 false false R65.htm 2458435 - Disclosure - Subsequent Events (Details) Sheet http://www.hepion.com/role/SubsequentEventsDetails Subsequent Events (Details) Details http://www.hepion.com/role/SubsequentEvents 65 false false All Reports Book All Reports hepa-20211231.htm hepa-20211231.xsd hepa-2021123110kxex211.htm hepa-2021123110kxex231.htm hepa-2021123110kxexx311.htm hepa-2021123110kxexx312.htm hepa-2021123110kxexx321.htm hepa-2021123110kxexx322.htm hepa-20211231_cal.xml hepa-20211231_def.xml hepa-20211231_lab.xml hepa-20211231_pre.xml hepa-20211231_g1.jpg http://fasb.org/us-gaap/2021-01-31 http://xbrl.sec.gov/dei/2021q4 true true