The amount accrued related to the payments, to be made under License agreement.

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Minimum period for which entity must provide prior written notice in order to terminate agreement on a country by country basis, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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For contingent consideration arrangements recognized in connection with a business combination, this element represents an estimate of the high-end of the potential range (undiscounted) of the consideration which may be paid.

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Face amount or stated value per share of preferred stock nonredeemable or redeemable solely at the option of the issuer.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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The maximum number of shares (or other type of equity) that have been approved for issuance in the equity-based payment transaction.

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The fair value of stock issued in noncash financing activities.

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Commitments and Contingencies - License Agreement with Chimerix, Inc. (Details) - USD ($)		3 Months Ended		6 Months Ended
	Dec. 17, 2014	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Agreement
Research and development		$ 2,122,898	$ 3,259,983	$ 4,383,602	$ 6,204,635
License Agreement \| Chimerix Inc
Agreement
Potential milestone payment	$ 20,000,000
Agreement termination notice (in days)	60 days
Research and development	$ 1,200,000
Milestone payment accrual		$ 0		$ 0
License Agreement \| Chimerix Inc \| Series B convertible preferred stock
Agreement
Upfront payment (in shares)	120,000
Stated value (in dollars per share)	$ 10.00
Fair value of shares issued	$ 1,200,000