X0206 3 2021-08-01 0 0001583648 PIERIS PHARMACEUTICALS, INC. PIRS 0001875416 Olwill Shane C/O PIERIS PHARMACEUTICALS, INC. 255 STATE STREET, 9TH FLOOR BOSTON MA 02109 false true false false Chief Development Officer Common Stock 4638.00 D Stock Option (right to buy) 2.00 2024-12-17 Common Stock 145000.00 D Stock Option (right to buy) 1.52 2026-02-12 Common Stock 100000.00 D Stock Option (right to buy) 1.99 2027-02-23 Common Stock 56250.00 D Stock Option (right to buy) 0.00 2028-02-20 Common Stock 90000.00 D Stock Option (right to buy) 3.09 2029-02-26 Common Stock 82000.00 D Stock Option (right to buy) 3.15 2030-02-27 Common Stock 90000.00 D Stock Option (right to buy) 2.50 2031-03-04 Common Stock 150000.00 D The option has fully vested. The option vested as to 25% of the option shares on February 20, 2019 and vests as to an additional 6.25% of the option shares at the end of each successive three-month period thereafter. The option vested as to 25% of the option shares on February 26, 2020 and vests as to an additional 6.25% of the option shares at the end of each successive three-month period thereafter. The option vested as to 25% of the option shares on February 27, 2021 and vests as to an additional 6.25% of the option shares at the end of each successive three-month period thereafter. The option vested as to 25% of the option shares on March 4, 2022 and vests as to an additional 6.25% of the option shares at the end of each successive three-month period thereafter. /s/ Megan Gates, Attorney-in-Fact 2021-08-03