X0306 4 2017-08-16 0 0001583648 PIERIS PHARMACEUTICALS, INC. PIRS 0001714023 Reine Allan C/O PIERIS PHARMACEUTICALS, INC. 255 STATE STREET, 9TH FLOOR BOSTON MA 02109 0 1 0 0 See Remarks Common Stock 2017-08-16 4 P 0 45000 4.79 A 45000 D Common Stock 2017-08-17 4 P 0 20000 4.89 A 65000 D The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.69 to $4.90, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges sent forth in this footnote. SVP and Chief Financial Officer /s/ Caroline G. Gammill, Attorney-in-fact 2017-08-17