Income Taxes - Deferred income taxes (Details) - USD ($) $ in Thousands	Dec. 31, 2024	Dec. 31, 2023
Deferred tax assets:
Net operating loss carryforwards	$ 154,476	$ 153,225
Capital loss carryforwards	20,094	21,482
Research and development tax credit carryforwards	16,211	16,910
Fixed assets and intangibles	235,265	235,381
Share-based compensation	3,402	3,431
Accruals	1,674	1,186
Operating lease liabilities	11,296	10,946
Prepaid assets		(248)
Other	9,170	4,982
Subtotal	451,588	447,295
Valuation allowance	(435,543)	(429,850)
Total deferred tax assets	16,045	17,445
Deferred tax liabilities:
Operating lease assets	(7,814)	(8,076)
Future contingent milestone and royalty assets	(5,533)	(14,512)
Prepaid assets	(268)
Total deferred tax liabilities	(13,615)	(22,588)
Net deferred tax assets	2,430
Net deferred tax liabilities		(5,143)
Information related to valuation allowance
Valuation allowance	435,543	$ 429,850
Ireland
Information related to valuation allowance
Net operating loss carryforwards	1,170,000
Unused capital allowances	1,190,000
Capital loss carryforwards | Ireland
Information related to valuation allowance
R&D tax credit	60,900
State
Deferred tax assets:
Net operating loss carryforwards	98,900
State | Research and Development
Deferred tax assets:
Net operating loss carryforwards	$ 25,700