Property and Equipment (Details) - USD ($) $ in Thousands		12 Months Ended
		Dec. 31, 2024	Dec. 31, 2023
Property and Equipment
Property and equipment, gross		$ 29,819	$ 30,650
Less: accumulated depreciation		(22,401)	(21,582)
Property and equipment, net		7,418	9,068
Impairment charge		300
Impairment charges related to property and equipment			0
Depreciation expense		1,600	1,900
Carrying value	[1]	37,643	40,621
Proceeds from the sale of property and equipment			1,513
Non-cash loss			1,200
Computer equipment
Property and Equipment
Property and equipment, gross		2,060	1,883
Software
Property and Equipment
Property and equipment, gross		762	762
Furniture and fixtures
Property and Equipment
Property and equipment, gross		1,642	1,738
Laboratory equipment
Property and Equipment
Property and equipment, gross		38	60
Carrying value			2,700
Leasehold improvements
Property and Equipment
Property and equipment, gross		$ 25,317	26,207
Property and equipment
Property and Equipment
Proceeds from the sale of property and equipment			$ 1,500

[1] Amounts include share-based compensation expense as follows: