Segment Information - Segment loss, including significant segment expenses (Details) - USD ($) $ in Thousands		3 Months Ended								12 Months Ended
		Dec. 31, 2024	Sep. 30, 2024	Jun. 30, 2024	Mar. 31, 2024	Dec. 31, 2023	Sep. 30, 2023	Jun. 30, 2023	Mar. 31, 2023	Dec. 31, 2024	Dec. 31, 2023
Segment Information
Total revenues		$ 18,754	$ 16,868	$ 14,256	$ 14,503	$ 17,565	$ 15,693	$ 13,749	$ 10,417	$ 64,381	$ 57,424
Share-based compensation										21,393	25,371
Loss on impairment of long-lived assets										4,513
Restructuring and related expenses	[1]										2,743
Total expenses		27,954	27,705	29,961	25,710	23,805	24,453	29,872	35,329	111,330	113,459
Loss from operations		(9,200)	(10,837)	(15,705)	(11,207)	(6,240)	(8,760)	(16,123)	(24,912)	(46,949)	(56,035)
Interest expense (non-cash)										(2,546)	(2,350)
Interest and other income, net										4,881	9,116
Provision for income tax expense										(11,804)	(5,924)
Net loss		$ (15,527)	$ (12,698)	$ (16,529)	$ (11,664)	$ (8,510)	$ (8,950)	$ (15,645)	$ (22,088)	(56,418)	(55,193)
Single reportable segment
Segment Information
Total revenues										64,381	57,424
Employee-related (Research and development)										12,212	12,699
External-related (Research and development)										17,112	14,473
Facilities, depreciation, and other allocated expenses (Research and development)										3,215	5,401
Supporting general and administration functions										27,156	31,928
Sales and marketing, and medical affairs										25,729	21,202
Share-based compensation										21,393	25,013
Total recurring operating expenses										106,817	110,716
Loss on impairment of long-lived assets										4,513
Restructuring and related expenses											2,743
Total expenses										111,330	113,459
Loss from operations										(46,949)	(56,035)
Interest expense (non-cash)										(2,546)	(2,350)
Interest and other income, net										4,881	9,116
Provision for income tax expense										(11,804)	(5,924)
Net loss										$ (56,418)	$ (55,193)

[1] Amounts include share-based compensation expense as follows: