CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Operating activities
Net loss	$ (11,664)	$ (22,088)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Depreciation and amortization	432	625
Amortization and accretion income, net	(354)	(678)
Future royalty payment contingency interest accretion	629	550
Share-based compensation	5,229	7,021
(Gain) loss on disposal of property and equipment		29
Amortization of right-of-use assets	1,101	1,031
Deferred income taxes	(513)
Changes in operating assets and liabilities:
Receivables from collaborative and licensing arrangements	2,810	4,515
Prepaid clinical and development services	(48)	(13)
Other prepaid and current assets	4,034	1,401
Right-of-use lease assets	(178)	(109)
Other assets	148	1,270
Accounts payable	184	1,002
Accrued personnel-related expenses, accrued clinical and development expenses, and other accrued liabilities	(3,396)	(4,337)
Deferred revenue		(6)
Operating lease liabilities	(1,256)	(966)
Unrecognized tax benefits	1,781
Other long-term liabilities	39	(468)
Net cash used in operating activities	(1,022)	(11,221)
Investing activities
Purchases of property and equipment	(91)	(938)
Purchases of marketable securities	(26,902)	(134,533)
Maturities of marketable securities	44,021	29,500
Sale of short-term investments and marketable securities		62,715
Proceeds from the sale of property and equipment		210
Net cash provided by (used in) investing activities	17,028	(43,046)
Financing activities
Ordinary share repurchases	(445)	(55,353)
Repurchase of shares to satisfy tax withholding	(1,271)	(887)
Net cash used in financing activities	(1,716)	(56,240)
Net increase (decrease) in cash, cash equivalents, and restricted cash	14,290	(110,507)
Cash, cash equivalents, and restricted cash at beginning of period	40,381	299,008
Cash, cash equivalents, and restricted cash at end of period	54,671	188,501
Supplemental disclosure of cash flow information
Cash paid for income taxes, net	$ (9)	7
Supplemental disclosure of non-cash activities
Recognition of tenant improvement allowance assigned to sublease		$ 6,490