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Capital Return Program (Details) - USD ($)
12 Months Ended
Nov. 22, 2022
Nov. 21, 2022
Sep. 28, 2022
Sep. 20, 2022
Dec. 31, 2023
Dec. 31, 2022
Feb. 28, 2023
Sep. 30, 2022
Capital Return Program                
Share repurchase authorized amount           $ 250,000,000.0 $ 325,000,000.0  
Ordinary shares, par value (in dollars per share)         $ 0.00001 $ 0.00001    
Ordinary shares, shares outstanding (in shares)         48,091,000 65,227,000    
Consideration for repurchase         $ 197,051,000 $ 128,830,000    
Aggregate cost         197,052,000 128,830,000    
Net cash proceeds from sale of R&D laboratory equipment         $ 1,513,000 $ 1,866,000    
GSK Share Repurchase                
Capital Return Program                
Share repurchase authorized amount               $ 250,000,000.0
Ordinary shares, par value (in dollars per share)       $ 0.00001        
Ordinary shares, shares outstanding (in shares)       0        
Shares authorized to be repurchased (in shares)       9,644,807        
Repurchase price (in dollars per share)       $ 9.75        
Consideration for repurchase       $ 94,000,000.0        
Modified Dutch Auction Tender Offer                
Capital Return Program                
Share repurchase authorized amount     $ 95,000,000.0          
Repurchase price (in dollars per share) $ 10.50              
Share repurchase (as a percent)   0.20%            
Repurchase of ordinary shares (in shares) 115,967 115,967            
Aggregate cost $ 1,200,000              
Modified Dutch Auction Tender Offer | Minimum                
Capital Return Program                
Repurchase price (in dollars per share)     $ 9.75          
Modified Dutch Auction Tender Offer | Maximum                
Capital Return Program                
Repurchase price (in dollars per share)     $ 10.50