Income Taxes - Deferred income taxes (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Deferred tax assets:
Net operating loss carryforwards	$ 153,225	$ 141,674
Capital loss carryforwards	21,482	19,409
Research and development tax credit carryforwards	16,910	16,176
Fixed assets and intangibles	235,381	245,822
Share-based compensation	3,431	4,298
Accruals	1,186	1,795
Operating lease liabilities	10,946	11,239
Prepaid assets	(248)	304
Other	4,982	30
Subtotal	447,295	440,747
Valuation allowance	(429,850)	(422,325)
Total deferred tax assets	17,445	18,422
Deferred tax liabilities:
Operating lease assets	(8,076)	(8,634)
Future contingent milestone and royalty assets	(14,512)	(11,725)
Total deferred tax liabilities	(22,588)	(20,359)
Net deferred tax liabilities	(5,143)	(1,937)
Information related to valuation allowance
Valuation allowance	429,850	$ 422,325
Ireland
Information related to valuation allowance
Net operating loss carryforwards	1,160
Unused capital allowances	1,040,000
Capital loss carryforwards | Ireland
Information related to valuation allowance
R&D tax credit	65,100
State
Deferred tax assets:
Net operating loss carryforwards	103,800
State | Research and Development
Deferred tax assets:
Net operating loss carryforwards	$ 25,900