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Income Taxes (Tables)
12 Months Ended
Dec. 31, 2023
Income Taxes  
Schedule of components of the income (loss) before income taxes

Year Ended December 31, 

(In thousands)

    

2023

    

2022

    

Income (loss) before provision for income taxes:

  

  

United States

$

1,151

$

(40,556)

Ireland

(50,420)

(52,168)

United Kingdom

(91)

Total

$

(49,269)

$

(92,815)

Schedule of the components of provision for income tax expense

Year Ended December 31, 

(In thousands)

    

2023

    

2022

    

Provision for income tax (expense) benefit:

Current:

United States

$

(2,881)

$

Ireland

(8)

United Kingdom

164

(1)

Subtotal

(2,717)

(9)

Deferred:

United States

(3,207)

Subtotal

(3,207)

Total

$

(5,924)

$

(9)

Effective tax rate

12.02

%  

(0.01)

%  

Schedule of the differences between the Irish statutory income tax rate for non-trading income and the Company's effective tax rates

Year Ended December 31, 

    

2023

    

2022

    

Provision at statutory income tax rate

25.00

%  

25.00

%

Foreign rate differential

(8.28)

 

(6.80)

 

Share-based compensation

(3.00)

(3.28)

Non-deductible executive compensation

(4.45)

(2.79)

Uncertain tax positions

(7.31)

(7.10)

Research and development tax credit carryforwards

3.34

2.65

Change in valuation allowance

(16.00)

 

(1.01)

 

Other

(1.32)

 

(6.68)

 

Effective tax rate

(12.02)

%  

(0.01)

%  

Significant components of the Company's deferred tax assets and liabilities

December 31, 

(In thousands)

    

2023

    

2022

Deferred tax assets:

Net operating loss carryforwards

 

$

153,225

$

141,674

Capital loss carryforwards

 

21,482

 

19,409

Research and development tax credit carryforwards

 

16,910

 

16,176

Fixed assets and intangibles

235,381

245,822

Share-based compensation

3,431

4,298

Accruals

1,186

1,795

Operating lease liabilities

10,946

11,239

Prepaid assets

(248)

304

Other

 

4,982

 

30

Subtotal

447,295

440,747

Valuation allowance

 

(429,850)

 

(422,325)

Total deferred tax assets

17,445

18,422

Deferred tax liabilities:

Operating lease assets

(8,076)

(8,634)

Future contingent milestone and royalty assets

(14,512)

(11,725)

Total deferred tax liabilities

(22,588)

(20,359)

Net deferred tax liabilities

$

(5,143)

$

(1,937)

Reconciliation of unrecognized tax benefits

(In thousands)

    

Unrecognized tax benefits as of December 31, 2021

$

75,023

Gross decrease in tax positions for prior years

(7,395)

Gross increase in tax positions for current year

8,371

Unrecognized tax benefits as of December 31, 2022

75,999

Gross decrease in tax positions for prior years

(632)

Gross increase in tax positions for current year

4,103

Unrecognized tax benefits as of December 31, 2023

$

79,470