Income Taxes - Deferred income taxes (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Components of Deferred Tax Assets [Abstract]
Net operating loss carryforwards	$ 104,236	$ 115,606
Capital loss carryforwards	19,409	19,409
Research and development tax credit carryforwards	16,176	28,372
Fixed assets and intangibles	283,260	287,177
Share-based compensation	4,298	10,432
Accruals	1,795	3,590
Operating lease liabilities	11,239	11,607
Prepaid assets	304
Other	30	10,505
Subtotal	440,747	486,698
Valuation allowance	(422,325)	(477,868)
Total deferred tax assets	18,422	8,830
Deferred tax liabilities:
Operating lease assets	(8,634)	(8,575)
Future contingent milestone and royalty assets	(11,725)
Prepaid assets		(255)
Total deferred tax liabilities	(20,359)	(8,830)
Net deferred tax assets (liabilities)	(1,937)
Information related to valuation allowance
Valuation allowance	422,325	$ 477,868
Ireland
Information related to valuation allowance
Net operating loss carryforwards	786,200
Capital loss carryforwards | Ireland
Information related to valuation allowance
R&D tax credit	58,800
State
Components of Deferred Tax Assets [Abstract]
Net operating loss carryforwards	102,700
State | Research and Development
Components of Deferred Tax Assets [Abstract]
Research and development tax credit carryforwards	$ 25,400