Leases (Details) $ in Thousands	1 Months Ended				12 Months Ended
	Jun. 30, 2022 USD ($) ft²	May 31, 2022 USD ($) ft²	Jul. 31, 2021 USD ($) ft²	Apr. 30, 2017 USD ($) ft²	Dec. 31, 2022 USD ($) ft² building item	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Lessee, Lease, Description [Line Items]
Area of leased space | ft²					162,000
Number of building leased | building					2
Tenant improvement allowance					$ 8,912	$ 10,200
Decrease in operating lease liabilities					1,024	1,742	$ (1,600)
Option to terminate sublease			false
Area of subleased property | ft²			21,000
Monthly base rent			$ 100
Increase in annual base rent (as a percent)			3.00%
Premium component in sublease income			$ 4,200
Percentage of excess sublease income over lease obligations received to be shared with lessor			50.00%
Premium component in sublease income to be shared with lessor			$ 2,100
Percentage of excess sublease income over lease obligations to be retained			50.00%
Expected sublease income			$ 13,100
Ireland
Lessee, Lease, Description [Line Items]
Tenant improvement allowance					(8,900)
Dublin
Lessee, Lease, Description [Line Items]
Area of leased space | ft²		700		6,100
Decrease in operating lease assets		$ 1,400
Decrease in operating lease liabilities		1,500
Loss on sale of furniture and equipment		$ 100
Lease term		2 years
Option to terminate		true
Lease termination notice period		3 months
Operating lease expenses		$ 400
Annual base rent expenses		$ 200		$ 400
South San Francisco
Lessee, Lease, Description [Line Items]
Area of subleased property | ft²	78,000
Expected sublease income					$ 5,000	$ 500
South San Francisco | Sublease
Lessee, Lease, Description [Line Items]
Option to terminate sublease	false
Annual base rent expenses	$ 800
Monthly base rent	$ 500
Increase in annual base rent (as a percent)	3.00%
Expects to receive base rent	$ 51,700
Premium component in sublease income	$ 13,500
Percentage of excess sublease income over lease obligations received to be shared with lessor	50.00%
Premium component in sublease income to be shared with lessor	$ 6,700
Percentage of excess sublease income over lease obligations to be retained	50.00%
Number of buildings in which office and laboratory space leased | item					2
Reduction in expenses	$ 6,500
Tenant improvement allowance	$ 8,900