CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenue:
Total revenue	$ 51,346	$ 55,311	$ 71,857
Expenses:
Research and development (1)	63,392	193,657	260,953
Selling, general and administrative (1)	67,073	99,296	108,531
Restructuring and related expenses (1)	12,838	20,142
Total expenses	143,303	313,095	369,484
Loss from operations	(91,957)	(257,784)	(297,627)
Interest expense	(6,369)	(8,547)	(8,547)
Loss on extinguishment of debt	(3,034)
Interest income and other income, net	8,545	1,109	2,831
Loss from continuing operations before income taxes	(92,815)	(265,222)	(303,343)
Provision for income tax (expense) benefit	(9)	151	8,520
Net loss from continuing operations	(92,824)	(265,071)	(294,823)
Income from discontinued operations before income taxes	1,143,930	65,645	16,806
Provision for income tax expense	(178,974)
Net income from discontinued operations	964,956	65,645	16,806
Net income (loss)	$ 872,132	$ (199,426)	$ (278,017)
Net income (loss) per share:
Continuing operations - basic	$ (1.26)	$ (3.82)	$ (4.73)
Continuing operations - diluted	(1.26)	(3.82)	(4.73)
Discontinued operations - basic	13.11	0.95	0.27
Discontinued operations - diluted	13.11	0.95	0.27
Net income (loss) - basis	11.85	(2.87)	(4.46)
Net income (loss) - diluted	$ 11.85	$ (2.87)	$ (4.46)
Shares used to compute basis and diluted net income (loss) per share	73,591	69,461	62,345
Shares used to compute basis and diluted net income (loss) per share	73,591	69,461	62,345
Total share-based compensation expense	$ 39,734	$ 62,061	$ 62,976
Research and development
Expenses:
Restructuring and related expenses (1)	5,900	10,600
Net income (loss) per share:
Total share-based compensation expense	12,888	25,634	31,294
Selling, general and administrative
Expenses:
Restructuring and related expenses (1)	6,900	9,500
Net income (loss) per share:
Total share-based compensation expense	19,848	28,065	31,682
Restructuring and related expenses
Net income (loss) per share:
Total share-based compensation expense	6,998	8,362
Viatris collaboration agreement
Revenue:
Total revenue	48,624	43,848	43,893
Viatris royalties (Non-US)
Revenue:
Total revenue	30
Collaboration revenue
Revenue:
Total revenue	192	$ 11,463	26,464
Licensing revenue
Revenue:
Total revenue	$ 2,500		$ 1,500