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Share-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2022
Share-Based Compensation  
Schedule of share-based compensation expense included in the consolidated statements of operations

Year Ended December 31, 

(In thousands)

    

2022

    

2021

2020

Research and development

$

12,888

$

25,634

$

31,294

Selling, general and administrative

 

19,848

 

28,065

 

31,682

Restructuring and related expenses

6,998

8,362

Total share-based compensation expense

$

39,734

$

62,061

$

62,976

Schedule of share-based compensation expense by award type included in the consolidated statements of operations

Year Ended December 31, 

(In thousands)

    

2022

    

2021

    

2020

Options

$

2,998

$

5,473

$

6,536

RSUs

35,726

54,931

49,803

Performance RSAs and RSUs

237

763

3,943

ESPP

 

773

894

2,694

Total share-based compensation expense

39,734

$

62,061

$

62,976

Schedule of unrecognized compensation cost, net of expected forfeitures, and the estimated weighted-average amortization period, using the straight-line attribution method

 

Unrecognized

WeightedAverage

 

Compensation

Amortization Period

(In thousands, except amortization period)

    

Cost

    

(Years)

Options

$

3,453

2.75

RSUs

39,721

2.50

Performance RSAs and RSUs (1)

0.64

ESPP

229

0.51

Total

$

43,403

(1)Represents unrecognized share-based compensation cost associated with the Company’s performance-contingent awards described above that are probable of vesting.
Summary of option activity under the 2013 EIP and 2014 NEEIP

Weighted-Average

    

Number of Shares 

Weighted-Average

Exercise Price of

Aggregate

Subject to

Remaining Contractual

Outstanding Options

Intrinsic Value

Outstanding Options

Term (Years)

(in dollars)

(in thousands)

Outstanding at December 31, 2021

2,871,568

$

24.62

Granted

753,400

10.19

Exercised

-

Forfeited

(1,213,075)

25.69

Outstanding at December 31, 2022

2,411,893

5.24

19.53

$

775

Exercisable at December 31, 2022

3.69

142

Vested and expected to vest at December 31, 2022

5.24

775

2022

    

2021

2020

Weighted average fair value of options (in dollars)

$

5.33

$

9.25

$

11.03

Total intrinsic value of options exercised (in thousands)

$

$

1

$

384

Schedule of RSU and RSA activity (including performance RSUs and RSAs)

    

Number of Shares

    

Number of Shares

Subject to

Outstanding Subject to

Outstanding RSUs

Performance Conditions (RSAs)

Outstanding at December 31, 2021

8,353,849

 

Granted

648,065

Released

(3,766,876)

Forfeited

(1,125,191)

Outstanding at December 31, 2022

4,109,847

 

Schedule of range of assumptions used to estimate the fair value of share options granted and rights granted

Year Ended December 31, 

    

2022

    

2021

    

2020

Options

Risk-free interest rate

 

1.5% - 3.8%

0.5% - 1.2%

0.3% - 1.7%

Expected term (in years)

 

5.3 - 6.1

5.3 - 6.1

5.2 - 6.1

Volatility

 

55% - 70%

52% - 53%

50% - 53%

Dividend yield

 

Weighted-average estimated fair value

$

5.33

$

9.25

$

11.03

2013 ESPP

Risk-free interest rate

1.5% - 4.57%

0.03% - 0.2%

0.1% - 0.2%

Expected term (in years)

0.5 - 2.0

0.5 - 2.0

0.5 - 2.0

Volatility

41% - 72%

40% - 79%

53% - 76%

Dividend yield

Weighted-average estimated fair value

$

3.86

$

3.52

$

8.04