CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 298,172	$ 89,959
Short-term marketable securities	29,312	83,506
Receivables from collaborative arrangements	16,785	14,065
Prepaid clinical and development services	1,513	10,245
Other prepaid and current assets	7,682	8,561
Amounts due from TRC, LLC (Discontinued operations)		43,534
Total current assets	353,464	249,870
Property and equipment, net	11,875	13,657
Operating lease assets	40,126	39,690
Future contingent milestone and royalty assets	194,200
Restricted cash	836	837
Other assets	6,899	3,228
Equity in net assets of TRC, LLC (Discontinued operations)		67,537
Total assets	607,400	374,819
Current liabilities:
Accounts payable	1,554	3,098
Accrued personnel-related expenses	10,314	12,796
Accrued clinical and development expenses	4,932	17,010
Accrued general and administrative expenses	4,020	2,898
Operating lease liabilities	6,753	503
Deferred revenue	24	98
Other accrued liabilities	1,118	1,304
Accrued interest payable		1,246
Current portion of non-recourse notes due 2035, net (Discontinued operations)		16,940
Accrued interest payable (Discontinued operations)		2,694
Total current liabilities	28,715	58,587
Long-term operating lease liabilities	45,407	52,681
Future royalty payment contingency	25,438
Long-term deferred revenue	192	310
Unrecognized tax benefits	64,191	240
Other long-term liabilities	1,657	2,180
Convertible senior notes due 2023, net		228,035
Non-recourse notes due 2035, net		371,359
Commitments and contingencies
Shareholders' Equity (Deficit)
Preferred shares, $0.00001 par value: 230 shares authorized, no shares issued or outstanding
Ordinary shares, $0.00001 par value: 200,000 shares authorized; [65,227] and 74,435 shares issued and outstanding at December 31, 2022 and December 31, 2021, respectively	1	1
Additional paid-in capital	1,295,725	1,387,469
Accumulated other comprehensive loss	(15)
Accumulated deficit	(853,911)	(1,726,043)
Total shareholders' equity (deficit)	441,800	(338,573)
Total liabilities and shareholders' equity (deficit)	$ 607,400	$ 374,819