Investments and Fair Value Measurements - Available-for-sale securities (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Available for sale securities:
Amortized Cost	$ 475,044	$ 133,738
Gross Unrealized Gains		1
Gross Unrealized Losses	(121)	(5)
Estimated Fair Value	474,923	133,734
Debt Securities, Available-for-sale, Unrealized Gain (Loss) [Abstract]
Estimated Fair Value lesser than 12 months	77,249	35,017
Estimated Fair Value Total	77,249	35,017
Gross unrealized lesser than 12 months	(121)	(5)
Gross unrealized loss, Total	(121)	(5)
Marketable securities
Available for sale securities:
Amortized Cost	77,370	83,510
Gross Unrealized Gains		1
Gross Unrealized Losses	(121)	(5)
Estimated Fair Value	77,249	83,506
U.S. government securities
Debt Securities, Available-for-sale, Unrealized Gain (Loss) [Abstract]
Estimated Fair Value lesser than 12 months	3,979	19,991
Estimated Fair Value Total	3,979	19,991
Gross unrealized lesser than 12 months	(8)	(2)
Gross unrealized loss, Total	(8)	(2)
U.S. government securities \| Quoted Prices in Active Markets for Identical Assets, Level 1
Available for sale securities:
Amortized Cost	3,987	29,986
Gross Unrealized Losses	(8)	(2)
Estimated Fair Value	3,979	29,984
U.S. corporate notes
Debt Securities, Available-for-sale, Unrealized Gain (Loss) [Abstract]
Estimated Fair Value lesser than 12 months	11,968	5,031
Estimated Fair Value Total	11,968	5,031
Gross unrealized lesser than 12 months	(38)	(2)
Gross unrealized loss, Total	(38)	(2)
U.S. corporate notes \| Significant Other Observable Inputs, Level 2
Available for sale securities:
Amortized Cost	12,006	5,034
Gross Unrealized Losses	(38)	(2)
Estimated Fair Value	11,968	5,032
U.S. commercial paper
Debt Securities, Available-for-sale, Unrealized Gain (Loss) [Abstract]
Estimated Fair Value lesser than 12 months	61,302	9,995
Estimated Fair Value Total	61,302	9,995
Gross unrealized lesser than 12 months	(75)	(1)
Gross unrealized loss, Total	(75)	(1)
U.S. commercial paper \| Significant Other Observable Inputs, Level 2
Available for sale securities:
Amortized Cost	61,377	48,490
Gross Unrealized Gains		1
Gross Unrealized Losses	(75)	(1)
Estimated Fair Value	61,302	48,490
Money market funds \| Quoted Prices in Active Markets for Identical Assets, Level 1
Available for sale securities:
Amortized Cost	397,674	50,228
Estimated Fair Value	$ 397,674	$ 50,228

Amount, before tax, of unrealized gain in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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