CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 418,538	$ 89,959
Short-term marketable securities	68,294	83,506
Receivables from collaborative arrangements	14,114	14,065
Prepaid clinical and development services	2,645	10,245
Other prepaid and current assets	8,127	8,561
Amounts due from TRC, LLC (Discontinued operations)		43,534
Total current assets	511,718	249,870
Property and equipment, net	11,884	13,657
Operating lease assets	39,992	39,690
Future contingent milestone and royalty assets	194,200
Restricted cash	836	837
Other assets	4,866	3,228
Equity in net assets of TRC, LLC (Discontinued operations)		67,537
Total assets	763,496	374,819
Current liabilities:
Accounts payable	5,337	3,098
Accrued personnel-related expenses	7,560	12,796
Accrued clinical and development expenses	4,078	17,010
Accrued general and administrative expenses	3,749	2,898
Operating lease liabilities	692	503
Deferred revenue	24	98
Current portion of non-recourse notes due 2035, net		16,940
Accrued interest payable		1,246
Other accrued liabilities	142	1,304
Income tax payable (Discontinued operations)	120,550
Accrued interest payable (Discontinued operations)		2,694
Total current liabilities	142,132	58,587
Long-term operating lease liabilities	51,381	52,681
Future royalty payment contingency	24,888
Long-term deferred revenue	199	310
Unrecognized Tax Benefits	62,661	240
Other long-term liabilities	1,657	2,180
Non-recourse notes due 2035, net		371,359
Convertible senior notes due 2023, net		228,035
Commitments and contingencies
Shareholders' Equity (Deficit)
Preferred shares, $0.00001 par value: 230 shares authorized, no shares issued or outstanding
Ordinary shares, $0.00001 par value: 200,000 shares authorized; 67,366 and 74,435 shares issued and outstanding at September 30, 2022 and December 31, 2021, respectively	1	1
Additional paid-in capital	1,324,247	1,387,469
Accumulated other comprehensive loss	(121)
Accumulated deficit	(843,549)	(1,726,043)
Total shareholders' equity (deficit)	480,578	(338,573)
Total liabilities and shareholders' equity (deficit)	$ 763,496	$ 374,819