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Share-Based Compensation - Performance Contingent Awards (Details)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Sep. 30, 2021
USD ($)
Jun. 30, 2022
USD ($)
Jun. 30, 2021
USD ($)
Jun. 30, 2022
USD ($)
employee
shares
Jun. 30, 2021
USD ($)
Share-Based Compensation          
Incremental Share-Based Compensation expense   $ 400   $ 1,700  
Cumulative compensation cost $ 800        
Total share-based compensation expense   9,709 $ 14,941 24,254 $ 30,773
Research and development          
Share-Based Compensation          
Total share-based compensation expense   3,556 7,315 8,086 15,236
Selling, general and administrative          
Share-Based Compensation          
Total share-based compensation expense   5,794 7,626 $ 11,292 15,537
Restructuring and related expenses          
Share-Based Compensation          
Incremental Share-Based Compensation expense $ 2,500        
Number of employees reduction in workforce | employee       45  
Total share-based compensation expense   359   $ 4,876  
Performance-Contingent Awards - RSUs          
Share-Based Compensation          
RSUs outstanding (in shares) | shares       305,000  
Performance-Contingent Awards - RSUs.          
Share-Based Compensation          
Total share-based compensation expense   $ 100 $ 100 $ 200 $ 600
Maximum potential expense | Performance-Contingent Awards - RSUs.          
Share-Based Compensation          
Total share-based compensation expense       $ 2,500