CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenue:
Total revenue	$ 11,050	$ 12,914	$ 24,246	$ 27,171
Expenses:
Research and development (1)	15,571	51,093	38,824	118,692
Selling, general and administrative (1)	16,986	25,931	34,828	56,481
Transaction-related legal expenses (Note 13)	3,778		5,057
Restructuring and related expenses (1)	1,594		10,918
Total expenses	37,929	77,024	89,627	175,173
Total share-based compensation expense	9,709	14,941	24,254	30,773
Loss from operations	(26,879)	(64,110)	(65,381)	(148,002)
Income from investment in TRC, LLC	28,127	21,926	53,237	38,473
Interest expense	(11,884)	(11,612)	(23,539)	(23,485)
Interest income and other income (expense), net	2,440	1,171	2,065	937
Loss before income taxes	(8,196)	(52,625)	(33,618)	(132,077)
Provision for income tax benefit (expense)	5	220	(519)	(7)
Net loss	(8,191)	(52,405)	(34,137)	(132,084)
Net unrealized loss on available-for-sale investments	(17)	(9)	(45)	(39)
Total comprehensive loss	$ (8,208)	$ (52,414)	$ (34,182)	$ (132,123)
Net loss per share:
Basic net loss per share	$ (0.11)	$ (0.80)	$ (0.45)	$ (2.03)
Diluted net loss per share	$ (0.11)	$ (0.80)	$ (0.45)	$ (2.03)
Shares used to compute basic net loss per share	76,270	65,669	75,761	65,085
Shares used to compute diluted net loss per share	76,270	65,669	75,761	65,085
Research and development
Expenses:
Restructuring and related expenses (1)	$ 400		$ 5,100
Total share-based compensation expense	3,556	$ 7,315	8,086	$ 15,236
Selling, general and administrative
Expenses:
Restructuring and related expenses (1)	1,200		5,800
Total share-based compensation expense	5,794	7,626	11,292	15,537
Restructuring and related expenses
Expenses:
Total share-based compensation expense	359		4,876
Viatris collaboration agreement
Revenue:
Total revenue	10,878	10,934	21,565	21,319
Collaborative revenue
Revenue:
Total revenue	$ 172	$ 1,980	181	$ 5,852
Licensing revenue
Revenue:
Total revenue			$ 2,500