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Share-Based Compensation - Performance Contingent Awards (Details)
$ in Thousands
1 Months Ended 3 Months Ended
Sep. 30, 2021
USD ($)
Mar. 31, 2022
USD ($)
employee
shares
Mar. 31, 2021
USD ($)
Share-Based Compensation      
Incremental Share-Based Compensation expense   $ 1,300  
Cumulative compensation cost $ 300    
Total share-based compensation expense   14,545 $ 15,832
Research and development      
Share-Based Compensation      
Total share-based compensation expense   4,530 7,921
Selling, general and administrative      
Share-Based Compensation      
Total share-based compensation expense   $ 5,498 7,911
Restructuring and related expenses      
Share-Based Compensation      
Incremental Share-Based Compensation expense $ 1,600    
Number of employees reduction in workforce | employee   40  
Total share-based compensation expense   $ 4,517  
Performance-Contingent Awards - RSUs      
Share-Based Compensation      
RSUs outstanding (in shares) | shares   305,000  
Performance-Contingent Awards - RSUs.      
Share-Based Compensation      
Total share-based compensation expense   $ 100 $ 500
Maximum potential expense | Performance-Contingent Awards - RSUs.      
Share-Based Compensation      
Total share-based compensation expense   $ 2,600