Corporate Restructuring (Details) $ in Thousands			3 Months Ended	12 Months Ended
	Nov. 30, 2021	Sep. 15, 2021 employee	Mar. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)
Corporate Restructuring
Reduction in workforce (as a percent)	75.00%	75.00%
Number of employees reduction in workforce | employee		270
Cash expenses related to the costs of employee severance				$ 17,000
Restructuring costs				20,142
Non-cash charges related to modification of equity-awards for terminated and remaining employee				15,000
Forecast
Corporate Restructuring
Cash expenses related to the costs of employee severance			$ 12,000
Restructuring costs			5,000
Non-cash charges related to modification of equity-awards for terminated and remaining employee			$ 7,000
Research and development
Corporate Restructuring
Restructuring costs				10,600
Selling, general and administrative
Corporate Restructuring
Restructuring costs				9,500
Severance
Corporate Restructuring
Cash expenses related to the costs of employee severance				11,500
Employee-related separation costs				20,100
Non-cash charges related to modification of equity-awards for terminated and remaining employee				8,600
Minimum
Corporate Restructuring
Employee-related separation costs				$ 32,000