Income Taxes - Deferred income taxes (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Components of Deferred Tax Assets [Abstract]
Net operating loss carryforwards	$ 115,606	$ 82,821
Capital loss carryforwards	19,409	19,409
Research and development tax credit carryforwards	28,372	24,075
Fixed assets and intangibles	287,177	310,187
Share-based compensation	10,432	15,087
Accruals	3,590	8,145
Operating lease liabilities	11,607	11,662
Other	10,505	346
Subtotal	486,698	471,732
Valuation allowance	(477,868)	(462,711)
Total deferred tax assets	8,830	9,021
Deferred tax liabilities:
Operating lease assets	(8,575)	(8,680)
Prepaid assets	(254)	(341)
Total deferred tax liabilities	(8,830)	(9,021)
Information related to valuation allowance
Valuation allowance	477,868	$ 462,711
Ireland
Information related to valuation allowance
Net operating loss carryforwards	739,600
Research and Development
Components of Deferred Tax Assets [Abstract]
Net operating loss carryforwards	260,100
Capital loss carryforwards | Ireland
Information related to valuation allowance
R&D tax credit	58,800
Federal
Components of Deferred Tax Assets [Abstract]
Net operating loss carryforwards	305,000
Federal | Research and Development
Components of Deferred Tax Assets [Abstract]
Research and development tax credit carryforwards	24,700
State
Components of Deferred Tax Assets [Abstract]
Net operating loss carryforwards	90,400
State | Research and Development
Components of Deferred Tax Assets [Abstract]
Research and development tax credit carryforwards	$ 23,400