Number of employees reduction in workforce.

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- Definition

Amount of cost capitalized for award reversed under share-based payment arrangement.

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No definition available.

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- Definition

The amount of maximum expense under share based compensation arrangement.

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No definition available.

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Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

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- Definition

Period over which grantee's right to exercise award under share-based payment arrangement is no longer contingent on satisfaction of service or performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, combination of market, performance or service condition.

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- Definition

The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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No definition available.

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- Definition

Number of shares authorized for issuance under share-based payment arrangement.

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- Definition

An excess of the fair value of the modified award over the fair value of the award immediately before the modification.

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Share-Based Compensation - Performance Contingent Awards (Details) $ in Thousands		1 Months Ended	12 Months Ended
	Sep. 15, 2021 employee	Sep. 30, 2021 USD ($)	Dec. 31, 2021 USD ($) employee shares	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2016 shares
Share-Based Compensation
Incremental Share-Based Compensation expense			$ 2,800
Number of employees reduction in workforce \| employee	270
Cumulative compensation cost		$ 2,800
Total share-based compensation expense			62,061	$ 62,976	$ 60,450
Research and development
Share-Based Compensation
Total share-based compensation expense			25,634	31,294	28,953
Selling, general and administrative
Share-Based Compensation
Total share-based compensation expense			$ 28,065	31,682	31,497
Restructuring and related expenses
Share-Based Compensation
Incremental Share-Based Compensation expense		$ 5,600
Number of employees reduction in workforce \| employee			160
Total share-based compensation expense			$ 8,362
Performance-Contingent Awards - RSAs
Share-Based Compensation
Shares approved for grant (in shares) \| shares						1,575,000
Vesting period						5 years
Total Max. Expense			$ 2,900
Performance-Contingent Awards - RSUs
Share-Based Compensation
RSUs outstanding (in shares) \| shares			325,000
Performance-Contingent Awards - RSUs \| Senior management
Share-Based Compensation
Shares approved for grant (in shares) \| shares						135,000
Performance-Contingent Awards - RSUs.
Share-Based Compensation
Total share-based compensation expense			$ 400	1,000	1,000
First tranche
Share-Based Compensation
Total share-based compensation expense			$ 400	$ 3,000	$ 1,900