Investments and Fair Value Measurements - Available-for-sale securities (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Available for sale securities:
Amortized Cost	$ 133,738	$ 211,427
Gross Unrealized Gains	1	53
Gross Unrealized Losses	(5)	(6)
Estimated Fair Value	133,734	211,474
Debt Securities, Available-for-sale, Unrealized Gain (Loss) [Abstract]
Estimated Fair Value lesser than 12 months	35,017	44,420
Estimated Fair Value Total	35,017	44,420
Gross unrealized lesser than 12 months	(5)	(6)
Gross unrealized loss, Total	(5)	(6)
Marketable securities
Available for sale securities:
Amortized Cost	83,510	211,427
Gross Unrealized Gains	1	53
Gross Unrealized Losses	(5)	(6)
Estimated Fair Value	83,506	211,474
U.S. government securities
Debt Securities, Available-for-sale, Unrealized Gain (Loss) [Abstract]
Estimated Fair Value lesser than 12 months	19,991
Estimated Fair Value Total	19,991
Gross unrealized lesser than 12 months	(2)
Gross unrealized loss, Total	(2)
U.S. government securities \| Quoted Prices in Active Markets for Identical Assets, Level 1
Available for sale securities:
Amortized Cost	29,986	75,036
Gross Unrealized Gains		34
Gross Unrealized Losses	(2)
Estimated Fair Value	29,984	75,070
U.S. government agency securities \| Significant Other Observable Inputs, Level 2
Available for sale securities:
Amortized Cost		74,971
Gross Unrealized Gains		18
Estimated Fair Value		74,989
U.S. corporate notes
Debt Securities, Available-for-sale, Unrealized Gain (Loss) [Abstract]
Estimated Fair Value lesser than 12 months	5,031	5,045
Estimated Fair Value Total	5,031	5,045
Gross unrealized lesser than 12 months	(2)	(1)
Gross unrealized loss, Total	(2)	(1)
U.S. corporate notes \| Significant Other Observable Inputs, Level 2
Available for sale securities:
Amortized Cost	5,034	5,046
Gross Unrealized Losses	(2)	(1)
Estimated Fair Value	5,032	5,045
U.S. commercial paper
Debt Securities, Available-for-sale, Unrealized Gain (Loss) [Abstract]
Estimated Fair Value lesser than 12 months	9,995	39,375
Estimated Fair Value Total	9,995	39,375
Gross unrealized lesser than 12 months	(1)	(5)
Gross unrealized loss, Total	(1)	(5)
U.S. commercial paper \| Significant Other Observable Inputs, Level 2
Available for sale securities:
Amortized Cost	48,490	56,374
Gross Unrealized Gains	1	1
Gross Unrealized Losses	(1)	(5)
Estimated Fair Value	48,490	$ 56,370
Money market funds \| Quoted Prices in Active Markets for Identical Assets, Level 1
Available for sale securities:
Amortized Cost	50,228
Estimated Fair Value	$ 50,228

Amount, before tax, of unrealized gain in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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