Revenue - Revenue from Collaborative Arrangements (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Collaboration revenue recognized in the period from:
Revenue from collaborative arrangements	$ 11,463	$ 26,464	$ 31,245
Janssen
Collaboration revenue recognized in the period from:
Revenue from collaborative arrangements	11,425	26,426	31,096
Other
Collaboration revenue recognized in the period from:
Revenue from collaborative arrangements	38	38	154
Collaborative revenue
Collaboration revenue recognized in the period from:
Revenue from collaborative arrangements	$ 11,463	$ 26,464	$ 31,250