CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenue:
Total revenue	$ 55,311	$ 71,857	$ 73,414
Expenses:
Research and development (1)	193,657	260,953	219,248
Selling, general and administrative (1)	99,296	108,661	106,081
Restructuring and related expenses	20,142
Total expenses	313,095	369,614	325,329
Total share-based compensation expense	62,061	62,976	60,450
Loss from operations	(257,784)	(297,757)	(251,915)
Income from investment in TRC, LLC	103,987	68,438	33,705
Interest expense	(46,889)	(44,585)	(31,862)
Loss on extinguishment of debt		(15,464)
Interest and other income, net	1,109	2,831	8,395
Loss before income taxes	(199,577)	(286,537)	(241,677)
Provision for income tax benefit	151	8,520	5,222
Net loss	$ (199,426)	$ (278,017)	$ (236,455)
Net loss per share:
Basic net loss per share	$ (2.87)	$ (4.46)	$ (4.25)
Diluted net loss per share	$ (2.87)	$ (4.46)	$ (4.25)
Shares used to compute basic net loss per share	69,461	62,345	55,610
Shares used to compute diluted net loss per share	69,461	62,345	55,610
Research and development
Expenses:
Restructuring and related expenses	$ 10,600
Total share-based compensation expense	25,634	$ 31,294	$ 28,953
Selling, general and administrative
Expenses:
Restructuring and related expenses	9,500
Total share-based compensation expense	28,065	31,682	31,497
Restructuring and related expenses
Expenses:
Total share-based compensation expense	8,362
Collaborative revenue
Revenue:
Total revenue	11,463	26,464	31,250
Licensing revenue
Revenue:
Total revenue		1,500	28,500
Viatris collaboration agreement
Revenue:
Total revenue	$ 43,848	$ 43,893	$ 13,664