Income Taxes - Deferred income taxes (Details) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Components of Deferred Tax Assets [Abstract]
Net operating loss carryforwards	$ 82,821	$ 58,161
Capital loss carryforwards	19,409	19,409
Research and development tax credit carryforwards	24,075	15,723
Fixed assets and intangibles	310,187	285,341
Share-based compensation	15,087	15,480
Accruals	8,145	8,245
Operating lease liabilities	11,662	11,358
Other	346	7
Subtotal	471,732	413,724
Valuation allowance	(462,711)	(403,836)
Total deferred tax assets	9,021	9,888
Deferred tax liabilities:
Operating lease assets	(8,680)	(9,429)
Prepaid assets	(341)	(459)
Total deferred tax liabilities	(9,021)	(9,888)
Information related to valuation allowance
Valuation allowance	462,711	$ 403,836
Ireland
Information related to valuation allowance
Net operating loss carryforwards	565,800
Capital loss carryforwards | Ireland
Information related to valuation allowance
Tax credit carryforward amount	58,800
Federal
Information related to valuation allowance
Net operating loss carryforwards	209,800
Operating loss available	164,900
Federal | Research and Development
Information related to valuation allowance
Tax credit carryforward amount	21,100
State
Information related to valuation allowance
Net operating loss carryforwards	70,900
State | Research and Development
Information related to valuation allowance
Tax credit carryforward amount	$ 21,200